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Interleukin 21r, Ed (IL21R) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS610275

A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21 (1). The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex… More details

$850 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Interleukin 21R, ED (IL21R), Polyclonal Antibody
Full Product Name
Interleukin 21R, ED (IL-21R ED)
Product Gene Name
anti-IL21R antibody
Product Synonym Names
Anti -Interleukin 21R, ED (IL-21R ED)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Interleukin-21R. An approximately 60kD band can be detected.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C or colder. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
59,130 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (27413483..27463363). Location: 16p11
OMIM
605383
3D Structure
ModBase 3D Structure for Q9HBE5
Immunogen
Synthetic peptide (NITDQSGNYSQECGS) corresponding to amino acids 97 to 111 of human IL-21R precursor.
Positive Control
Human Raji and A431 cell lysates

Product Categories/Family for anti-IL21R antibody

Antibodies; Abs to Interleukin
Applications Tested/Suitable for anti-IL21R antibody
Western Blot (WB)
Application Notes for anti-IL21R antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 0.5-1ug/ml

Western Blot (WB) of anti-IL21R antibody

Western blot analysis of IL-21 receptor expression in human HepG2 cell lysate with IL-21 receptor at (A) 1 and (B) 2 ug /ml.
Rabbit Anti-IL21R Polyclonal Antibody – Cat# MBS610275

Immunofluorescence (IF) of anti-IL21R antibody

Immunofluorescence of IL-21 Receptor in Rat Lung cells with IL-21 Receptor at 20ug/mL.
Rabbit Anti-IL21R Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS610275

Immunohistochemistry (IHC) of anti-IL21R antibody

Immunohistochemistry of IL-21 receptor in rat lung with IL-21 receptor at 10ug/mL.
Rabbit Anti-IL21R Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS610275

Other Notes

Small volumes of anti-IL21R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL21R purchase

MBS610275 is an antibody targeting IL21R. Also known as Interleukin 21R, ED (IL-21R ED). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL21R. It may not necessarily be applicable to this product.

NCBI GI #
302034748
NCBI GeneID
50615
NCBI Accession #
NP_851565.4
UniProt Primary Accession #
Q9HBE5
UniProt Secondary Accession #
Q96HZ1; Q9HB91; A8K9E8; D3DWF7
UniProt Related Accession #
Q9HBE5
GenBank Nucleotide #
NM_181079.4
NCBI Official Full Name
interleukin-21 receptor isoform 2
NCBI Official Synonym Full Names
interleukin 21 receptor
NCBI Official Symbol
IL21R
NCBI Official Synonym Symbols
NILR; MGC10967
UniProt Protein Name
Interleukin-21 receptor
UniProt Synonym Protein Names
Novel interleukin receptor
Protein Family
Interleukin-21 receptor
UniProt Gene Name
IL21R
UniProt Synonym Gene Names
NILR
UniProt Entry Name
IL21R_HUMAN
NCBI Protein Information
interleukin-21 receptor; IL-21R; IL-21 receptor; OTTHUMP00000162453; novel interleukin receptor

NCBI Summary for IL21R

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq]
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UniProt Comments for IL21R

IL21R: This is a receptor for interleukin-21

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 16p11

Cellular Component: integral to membrane

Molecular Function: interleukin-21 receptor activity

Biological Process: natural killer cell activation

Disease: Ige Responsiveness, Atopic; Il21r Immunodeficiency
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Research Articles on IL21R

1. These findings suggest role(s) for IL-21 in both the acute and chronic stages of multiple sclerosis via direct effects on T and B lymphocytes and, demonstrated for the first time, also on neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL21R antibody

 Reference Product  PubMed Publications
 JAK1 antibody  >11 publications with IL21R and JAK1

Pathways associated with anti-IL21R antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-IL21R antibody

 Disease Name  Pubmed Publications
 Lupus Erythematosus, Systemic Antibodies  >16 publications with IL21R and Lupus Erythematosus, Systemic
 Kidney Diseases Antibodies  >7 publications with IL21R and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >6 publications with IL21R and Cell Transformation, Neoplastic
 Fibrosis Antibodies  >2 publications with IL21R and Fibrosis
 Uveitis Antibodies  >2 publications with IL21R and Uveitis
 Psoriasis Antibodies  >1 publications with IL21R and Psoriasis
 Kidney Neoplasms Antibodies  >1 publications with IL21R and Kidney Neoplasms

Organs/Tissues associated with anti-IL21R antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >365 publications with IL21R and Blood
 Bone Marrow Antibodies  >59 publications with IL21R and Bone Marrow
 Spleen Antibodies  >41 publications with IL21R and Spleen
 Lymph Node Antibodies  >30 publications with IL21R and Lymph Node
 Liver Antibodies  >27 publications with IL21R and Liver
 Thymus Antibodies  >27 publications with IL21R and Thymus
 Lymph Antibodies  >18 publications with IL21R and Lymph
 Kidney Antibodies  >14 publications with IL21R and Kidney
 Brain Antibodies  >13 publications with IL21R and Brain
 Vascular Antibodies  >10 publications with IL21R and Vascular
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