Goat Anti-SERPINA6 Polyclonal Antibody – Cat# MBS610308

Immunohistochemical staining for Serpin A6 in perfusion fixed, frozen sections of mouse liver using MBS610308 at 15ug/ml (overnight incubation at 4°C). HRP-conjugated anti-goat secondary antibody was used; staining was performed with DAB; tissue was counterstained wtih hematoxylin. Specific labeling was localized to the cytoplasm of the heptocytes.

SERPINA6 Antibody – Goat Polyclonal

Name: SERPINA6 Antibody; Polyclonal; Goat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS610308
Price: 1045 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS610308

Serpin A6 (also known as corticosteroid-binding globulin/CBG and Transcortin) is a 50-60kD, secreted glycoprotein member of the serpin family of protease inhibitors. It is produced by hepatocytes and transports >90% of circulating cortisol. Although Serpin A6… More details

$1045 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SERPINA6, Polyclonal Antibody

Full Product Name

SERPINA6 (Serine/Cysteine Proteinase Inhibitor, Clade A, Member 6, Corticosteroid-Binding Globulin, CBG, Transcortin)

Product Gene Name

anti-SERPINA6 antibody

Product Synonym Names

Anti -SERPINA6 (Serine/Cysteine Proteinase Inhibitor, Clade A, Member 6, Corticosteroid-Binding Globulin, CBG, Transcortin)

Clonality

Polyclonal

Isotype

IgG

Host

Goat

Species Reactivity

Mouse

Form/Format

Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.

Purity/Purification

Affinity Purified
Purified by Immunoaffinity chromatography.

Specificity

Recognizes mouse Serpin A6. Shows ~25% crossreactivty with recombinant rat Serpin A6 and <1% crossreactivity with recombinant human Serpin A1 and recombinant human Serpin A5 when tested in Direct ELISA.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

45,141 Da

Chromosome Location

Chromosome: 14; NC_000014.8 (94770585..94789688, complement). Location: 14q32.1

OMIM

122500

3D Structure

ModBase 3D Structure for P08185

Immunogen

Recombinant corresponding to aa23-397 from mouse Serpin A6, expressed in NSO cells (Accession # Q06770). Species Sequence Homology: rat; 78% and human; 57%.

Product Categories/Family for anti-SERPINA6 antibody

Antibodies; Abs to Protease Inhibitors

Applications Tested/Suitable for anti-SERPINA6 antibody

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-SERPINA6 antibody

Suitable for use in Western Blot, Immunohistochemistry and Direct ELISA.
Dilution: Western Blot: 0.1-0.2ug/ml detects mouse Serpin 6. Detection limit for recombinant mouse Serpin 6 is ~0.5ng/ml under non-reducing and reducing conditions.
Immunohistochemistry: 5-15ug/ml detects mouse Serpin 6 in cells and tissues.
Direct ELISA: 0.5-1ug/ml detects mouse Serpin 6. Detection limit for recombinant mouse Serpin 6 is ~0.5ng/well

Other Notes

Small volumes of anti-SERPINA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPINA6 purchase

MBS610308 is an antibody targeting SERPINA6. Also known as SERPINA6 (Serine/Cysteine Proteinase Inhibitor, Clade A, Member 6, Corticosteroid-Binding Globulin, CBG, Transcortin). Reactive in Mouse. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINA6. It may not necessarily be applicable to this product.

NCBI GI #

34785976

NCBI GeneID

866

UniProt Primary Accession #

P08185

UniProt Secondary Accession #

Q7Z2Q9; A8K456

UniProt Related Accession #

P08185

NCBI Official Full Name

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6

NCBI Official Synonym Full Names

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6

NCBI Official Symbol

SERPINA6

NCBI Official Synonym Symbols

CBG

UniProt Protein Name

Corticosteroid-binding globulin

UniProt Synonym Protein Names

Serpin A6; Transcortin

Protein Family

Corticosteroid-binding globulin

UniProt Gene Name

SERPINA6

UniProt Synonym Gene Names

CBG

UniProt Entry Name

CBG_HUMAN

NCBI Protein Information

corticosteroid-binding globulin; serpin A6; transcortin; corticosteroid binding globulin; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6

NCBI Summary for SERPINA6

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq]

UniProt Comments for SERPINA6

SERPINA6: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency). CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity; steroid binding

Biological Process: glucocorticoid metabolic process; transport

Disease: Corticosteroid-binding Globulin Deficiency

Research Articles on SERPINA6

1. Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SERPINA6 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>3 publications with SERPINA6 and Nervous System Diseases
Pain Antibodies	>3 publications with SERPINA6 and Pain
CORTICOSTEROID-BINDING GLOBULIN DEFICIENCY Antibodies	>3 publications with SERPINA6 and CORTICOSTEROID-BINDING GLOBULIN DEFICIENCY
Inflammation Antibodies	>2 publications with SERPINA6 and Inflammation
Obesity Antibodies	>2 publications with SERPINA6 and Obesity
Muscular Diseases Antibodies	>2 publications with SERPINA6 and Muscular Diseases
Liver Diseases Antibodies	>1 publications with SERPINA6 and Liver Diseases
Hypertension Antibodies	>1 publications with SERPINA6 and Hypertension
Sleep Disorders Antibodies	>1 publications with SERPINA6 and Sleep Disorders
Neoplasms Antibodies	>1 publications with SERPINA6 and Neoplasms

Organs/Tissues associated with anti-SERPINA6 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>7 publications with SERPINA6 and Liver
Kidney Antibodies	>2 publications with SERPINA6 and Kidney
Ovary Antibodies	>1 publications with SERPINA6 and Ovary
Heart Antibodies	>1 publications with SERPINA6 and Heart