Rabbit Anti-CLCN1 Polyclonal Antibody – Cat# MBS610348

CLCN1 Antibody – Rabbit Polyclonal

Name: CLCN1 Antibody; Polyclonal; Rabbit; Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS610348
Price: 905 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS610348

Chloride is a critical component of all living cells. Voltage-gated chloride channels regulate cellular traffic of chloride ion. The chloride channels (CIC or CLC) performs several functions including the regulation of cell volume, membrane potential… More details

$905 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CLC1 (CLCN1), Polyclonal Antibody

Full Product Name

CLC1 (Clcn1, Chloride Channel)

Product Gene Name

anti-CLCN1 antibody

Product Synonym Names

Anti -CLC1 (Clcn1, Chloride Channel)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Rat

Form/Format

Supplied as a liquid in PBS, 0.05% sodium azide.

Purity/Purification

Serum
Serum

Specificity

Recognizes rat CLC1. No significant sequence homology is detected with other CLCs or other proteins.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

108,626 Da

Chromosome Location

Chromosome: 7; NC_000007.13 (143013219..143049097). Location: 7q32-qter; 7q35

OMIM

118425

3D Structure

ModBase 3D Structure for P35523

Immunogen

Synthetic peptide corresponding to an 18aa sequence near the C-terminus of rat CLC-1 (1), (KLH). Species sequence homology: mouse, canine and human -100%.

Product Categories/Family for anti-CLCN1 antibody

Antibodies; Abs to Ion Channel

Applications Tested/Suitable for anti-CLCN1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-CLCN1 antibody

Dilution: Western Blot: 1:1000-1:5000
ELISA: 1:10,000-50,000. C5837-02E Control peptide can be used to coat ELISA plates at 1ug/ml.

Other Notes

Small volumes of anti-CLCN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLCN1 purchase

MBS610348 is an antibody targeting CLCN1. Also known as CLC1 (Clcn1, Chloride Channel). Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CLCN1. It may not necessarily be applicable to this product.

NCBI GI #

119433677

NCBI GeneID

1180

NCBI Accession #

NP_000074.2

UniProt Primary Accession #

P35523

UniProt Secondary Accession #

Q2M202; A4D2H5

UniProt Related Accession #

P35523; Q75L28

GenBank Nucleotide #

NM_000083.2

NCBI Official Full Name

chloride channel protein 1

NCBI Official Synonym Full Names

chloride channel 1, skeletal muscle

NCBI Official Symbol

CLCN1

NCBI Official Synonym Symbols

CLC1; MGC138361; MGC142055

UniProt Protein Name

Chloride channel protein 1

UniProt Synonym Protein Names

Chloride channel protein, skeletal muscle

Protein Family

Chloride channel protein

UniProt Gene Name

CLCN1

UniProt Synonym Gene Names

CLC1

UniProt Entry Name

CLCN1_HUMAN

NCBI Protein Information

chloride channel protein 1; clC-1; OTTHUMP00000202223; chloride channel protein, skeletal muscle

NCBI Summary for CLCN1

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). [provided by RefSeq]

UniProt Comments for CLCN1

CLCN1: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. Defects in CLCN1 are the cause of Thomsen disease (THD); also known as autosomal dominant myotonia congenita (MCD). THD is characterized by skeletal muscle stiffness (delayed relaxation), due to membrane hyperexcitability. A variant form of Thomsen disease is myotonia levior that is characterized by milder symptoms, later onset and absence of muscle hypo- and hypertrophy. Defects in CLCN1 are the cause of autosomal recessive myotonia congenita (MCR); also known as Becker disease. Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily.

Protein type: Membrane protein, integral; Transporter, ion channel; Membrane protein, multi-pass; Transporter; Channel, chloride

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: integral to plasma membrane; plasma membrane; sarcolemma

Molecular Function: chloride channel activity; voltage-gated chloride channel activity

Biological Process: muscle contraction; transport; action potential propagation; transmembrane transport

Disease: Myotonia Congenita, Autosomal Recessive; Myotonia Congenita, Autosomal Dominant

Research Articles on CLCN1

1. Closure of the common gate in ClC-1 channels is accompanied by a separation of the carboxyl-termini, whereas, with opening, the carboxyl-termini approach each other more closely.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLCN1 antibody

Reference Product	PubMed Publications
SP1 antibody	>1 publications with CLCN1 and SP1

Diseases associated with anti-CLCN1 antibody

Disease Name	Pubmed Publications
Neurodegenerative Diseases Antibodies	>59 publications with CLCN1 and Neurodegenerative Diseases
MYOTONIA CONGENITA, AUTOSOMAL RECESSIVE Antibodies	>59 publications with CLCN1 and MYOTONIA CONGENITA, AUTOSOMAL RECESSIVE
MYOTONIA CONGENITA, AUTOSOMAL DOMINANT Antibodies	>59 publications with CLCN1 and MYOTONIA CONGENITA, AUTOSOMAL DOMINANT
Myotonia Congenita Antibodies	>59 publications with CLCN1 and Myotonia Congenita
Neurologic Manifestations Antibodies	>16 publications with CLCN1 and Neurologic Manifestations
Kidney Diseases Antibodies	>2 publications with CLCN1 and Kidney Diseases

Organs/Tissues associated with anti-CLCN1 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>81 publications with CLCN1 and Muscle