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Profilin 2a (PFN2) Antibody – Chicken Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS610364

PFN2 protein is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. This antibody is directed against the full length isoform. More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Profilin 2a (Pfn2), Polyclonal Antibody
Full Product Name
Profilin 2a (PFN2, Profilin-2)
Product Gene Name
anti-Pfn2 antibody
Product Synonym Names
Anti -Profilin 2a (PFN2, Profilin-2)
Clonality
Polyclonal
Isotype
IgY
Host
Chicken
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Glycerol free.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Profilin 2a. Species Crossreactivity: Mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
15,002 Da
Chromosome Location
Chromosome: 2; NC_005101.3 (167359671..167365375, complement). Location: 2q31
3D Structure
ModBase 3D Structure for Q9EPC6
Immunogen
Synthetic peptide corresponding to aa1-140

Product Categories/Family for anti-Pfn2 antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-Pfn2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Pfn2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:2000

Western Blot (WB) of anti-Pfn2 antibody

Western Blot Test: E coli-derived fusion protein as test antigen. Affi-anti-PFN2 IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
Chicken Anti-PFN2 Polyclonal Antibody – Cat# MBS610364

Other Notes

Small volumes of anti-Pfn2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pfn2 purchase

MBS610364 is an antibody targeting Pfn2. Also known as Profilin 2a (PFN2, Profilin-2). Reactive in Human, Mouse, Rat. Host: Chicken.

Additional Details

NCBI/Uniprot data below describe general gene information for Pfn2. It may not necessarily be applicable to this product.

NCBI GI #
13540707
NCBI GeneID
81531
NCBI Accession #
NP_110500.1
UniProt Primary Accession #
Q9EPC6
UniProt Secondary Accession #
Q9JHU7
UniProt Related Accession #
Q9EPC6
GenBank Nucleotide #
NM_030873.1
NCBI Official Full Name
profilin-2
NCBI Official Synonym Full Names
profilin 2
NCBI Official Symbol
Pfn2
UniProt Protein Name
Profilin-2
UniProt Synonym Protein Names
Profilin II
UniProt Gene Name
Pfn2
UniProt Entry Name
PROF2_RAT
NCBI Protein Information
profilin-2; profilin II

NCBI Summary for Pfn2

binds actin; regulates the rate of actin polymerization [RGD, Feb 2006]

UniProt Comments for Pfn2

profilin 2: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Belongs to the profilin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Cellular Component: cytoskeleton; cytoplasm; terminal button

Molecular Function: actin monomer binding; phosphatidylinositol-4,5-bisphosphate binding; adenyl-nucleotide exchange factor activity; actin binding

Biological Process: regulation of actin filament polymerization; positive regulation of actin filament polymerization; negative regulation of actin filament polymerization; positive regulation of ATPase activity; positive regulation of stress fiber formation; positive regulation of actin filament bundle formation; actin cytoskeleton organization and biogenesis; positive regulation of peptidyl-serine phosphorylation
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Research Articles on Pfn2

1. The binding site for proline-rich peptides is pre-organized. The C-terminus 2a is well ordered in the absence of ligand peptide. Pfn2 binds to the neuronal protein palladin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Pfn2 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Signaling By Robo Receptor Pathway antibodies  Signaling By Robo Receptor Pathway Diagram

Diseases associated with anti-Pfn2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with Pfn2 and Neoplasms
 Nervous System Diseases Antibodies  >2 publications with Pfn2 and Nervous System Diseases
 Mental Disorders Antibodies  >1 publications with Pfn2 and Mental Disorders
 Kidney Diseases Antibodies  >1 publications with Pfn2 and Kidney Diseases
 Atrophy Antibodies  >1 publications with Pfn2 and Atrophy

Organs/Tissues associated with anti-Pfn2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with Pfn2 and Brain
 Kidney Antibodies  >3 publications with Pfn2 and Kidney
 Muscle Antibodies  >3 publications with Pfn2 and Muscle
 Testis Antibodies  >3 publications with Pfn2 and Testis
 Lung Antibodies  >2 publications with Pfn2 and Lung
 Spleen Antibodies  >1 publications with Pfn2 and Spleen
 Embryonic Tissue Antibodies  >1 publications with Pfn2 and Embryonic Tissue
 Liver Antibodies  >1 publications with Pfn2 and Liver
 Heart Antibodies  >1 publications with Pfn2 and Heart
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