NCKX1 Antibody – Rabbit Polyclonal

Ca2+ plays a critical role in intracellular signaling. Intracellular Ca2+ levels are tightly controlled by continuous removal of Ca2+ via ATP-driven Ca2+ pump in the endoplasmic reticulum and plasma membrane, and the Na+/Ca2+ exchangers (NCX), in the plasma membrane. NCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In most cells, 3 Na+ are exchanged for 1 Ca2+. Several genes code for the 3 NCX (NCX1, NCX2, and NCX3), and three in the NCKX family (NCKX1, NCKX2, NCKX3). NCX share significant sequence homology (~70%), display 11 TM domains, a large central, intracellular hydrophilic regulatory loop between TM5 and 6, extracellular N-terminus and cytoplasmic C-terminus. The N-terminal signal peptide is cleaved off from the mature exchanger protein.

• Poon S et al (1999) Am. J. Physiol. 278, C651-C660Tucker JE et al (1998) Invest. Opthalmol. 39, 435Walter MA et al (1998) Human Genet. 103, 411Reilander H et al (1992) EMBO J. 11, 1689Kim TSY et al (1998) J Biol. Chem. 273, 16561-16567

Small volumes of anti-NCKX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS610428 is an antibody targeting NCKX1. Also known as Anti - NCKX1 (K+-dependent, Na Ca Exchanger 1). Reactive in Rat. Host: Rabbit
Source: Rat.