B-Amyloid Peptide-Binding Protein Antibody – Rabbit Polyclonal

Both genetic and biochemical data have established that b-anyloid peptide (Ab) is a causative factor in neuronal death and the consequent diminuation of cognitive abilities observed in Alzheimer's disease.1,2 Plasma lipoproteins and their cell surface receptors influence sequestration and clearance on soluble Ab, contributing to the etiology of the disease.3,4 Ab may act as an initiating factor in the death of neurons by inducing signal pathways leading to apoptosis.5,6 b-amyloid peptide-binding protein (BBP) is a novel protein containing a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily that is important in heterotrimeric G protein activation.7 BBP binds human b-amyloid peptide in vitro with high affinity and specificity. Expression of BBP in cell culture induces caspase-dependent vulnerability to b-amyloid peptide toxicity, suggesting that BBP mediates this cellular vulnerability through a G protein-regulated program of cell death. 7

Small volumes of anti-b-Amyloid Peptide-binding protein antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS610438 is an antibody targeting b-Amyloid Peptide-binding protein. Also known as b-Amyloid Peptide-binding protein (BBP). Reactive in Human, Mouse, Rat. Host: Rabbit.