Threonine-X-Arginine Antibody – Rabbit Polyclonal

Some important signaling proteins can be regulated by phosphorylation at a specific threonine followed by arginine or lysine at the +2 position. For example, conventional PKC isozymes phosphorylate substrates containing serine or threonine with Arg or Lys at the-3,-2 and +2 positions (1-2). c-Raf, a mitogen-activated protein kinase and the main effector recruited by GTP-bound Ras, is phosphorylated at Thr481 and Thr491 followed by Lys at the +2 position (3). APP1 and ERF also contain a phosphorylated Thr followed by Arg or Lys at the +2 position. Phosphorylation of these sites is important for their activities. In order to determine the phosphorylation state of Thr in the Thr-X-Arg motif and to identify potential new phosphorylation sites in this motif, antibodies have been developed that recognize phosphorylated Thr followed by Arg or Lys at the +2 position.

Small volumes of anti-Threonine-X-Arginine antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS610633 is an antibody targeting Threonine-X-Arginine. Also known as Threonine-X-Arginine (Thr-X-Arg), phosphorylated. Host: Rabbit.