Receptor (EPHA4) Antibody – Rabbit Polyclonal

EphA4: a tyrosine kinase receptor of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in hindbrain pattern formation. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.

Protein type: Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (receptor); Membrane protein, integral; EC 2.7.10.1; TK group; Eph family

Cellular Component: Golgi apparatus; cell surface; integral to plasma membrane; endoplasmic reticulum; postsynaptic density; dendrite; dendritic spine; integral to membrane; perikaryon; postsynaptic membrane; mitochondrial outer membrane; cell projection; membrane; axon; early endosome membrane; cytoplasm; plasma membrane; synapse; nerve terminal; cell junction; neuromuscular junction; endosome; filopodium

Molecular Function: identical protein binding; ephrin receptor binding; transmembrane-ephrin receptor activity; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; protein kinase activity; transferase activity; protein binding; GPI-linked ephrin receptor activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; ephrin receptor activity; kinase activity; PH domain binding; ATP binding

Biological Process: axon guidance; nervous system development; positive regulation of JNK activity; regulation of GTPase activity; peptidyl-tyrosine phosphorylation; negative regulation of axon regeneration; multicellular organismal development; protein amino acid autophosphorylation; motor axon guidance; regulation of astrocyte differentiation; positive regulation of dendrite morphogenesis; regulation of axonogenesis; glial cell migration; adult walking behavior; protein amino acid phosphorylation; ephrin receptor signaling pathway; cell adhesion; corticospinal tract morphogenesis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway