Cellular (fliP) Antibody – Rabbit Polyclonal

cFLIP (cellular FLICE-like inhibitory protein) is a cellular homologue of the viral protein, vFLIP, and is also known as CASH, Casper, CLARP, FLAME, I-FLICE, MRIT and Usurpin (2,3). cFLIP contains two death effector domains (DEDs) and is expressed as either a short or long splice variant called cFLIPs and cFLIPL, respectively (3,4). cFLIP can block Fas-mediated apoptosis presumably through the C-terminal region of cFLIPL which has homology with the proteolytic domain of caspase-8 (FLICE). However, cFLIP lacks the active proteinase site required for catalytic activity. Therefore, although it can be recruited to the ligated Fassignalling complex, it cannot deliver a death signal. cFLIP is expressed in the cytosol and it has been reported that cells with high levels of cFLIP relative to FLICE are generally resistant to apoptosis, whereas cells with low levels of cFLIP relative to FLICE are more sensitive to apoptosis (5). cFLIP acts as a caspase-8 dominant negative regulator, blocking apoptosis induced by the oligimerization of the adapter protein, FADD (5). cFLIP interacts with FADD and caspase-8 through their respective DEDs (2). The regulation and role of cFLIP in mediating signals that promote survival such as NF-kB versus inhibiting cell death by blocking cell death receptor-induced caspase activation is unclear (6).

Small volumes of anti-fliP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS611022 is an antibody targeting fliP. Also known as FLIP, cellular (cFLIP, FLICE Inhibitory Protein). Reactive in Human, Mouse, Rat. Host: Rabbit.