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L-685,458 ((5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6110373

Cell-permeable. A potent and selective -secretase inhibitor (IC50 = 17 nM). Displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of A 40 and A 42 peptides (IC50 values are 48 and 67nM… More details

$545 / 0.25 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
L-685,458, Biochemical
Full Product Name
L-685,458 ((5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide)
Form/Format
Supplied as a 1mM solution in DMSO.
Purity/Purification
Highly Purified
~98% (HPLC)
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
672.85
CAS Number
292632-98-5
Molecular Formula
C39H52N4O6

Product Categories/Family for L-685,458 biochemical

Biochemicals; Biochem-Inhibitors

Structure of L-685,458 biochemical

Structure of L-685,45.
L-685,458 ((5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide) Biochemical – Cat# MBS6110373

Other Notes

Small volumes of L-685,458 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for L-685,458 purchase

MBS6110373 is a biochemical targeting L-685,458. Also known as L-685,458 ((5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide).
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