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Lim-1 (LHX1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS611342

The LIM motif defines a zinc-binding domain that is found in a variety of transcriptional regulators and proto-oncogenes products. LIM domain mediates protein-protein interactions and, with LIM-homeodomain proteins, act as negative regulators of the… More details

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Product Overview

Online Datasheet in PDF
Product Name
Lim-1 (LHX1), Polyclonal Antibody
Full Product Name
Lim-1 (Homeobox Protein Lim1, LIM Homeobox Protein 1, LHX1, LIM/Homeobox Protein Lhx1, MGC126723, MGC138141)
Product Gene Name
anti-LHX1 antibody
Product Synonym Names
Anti -Lim-1 (Homeobox Protein Lim1, LIM Homeobox Protein 1, LHX1, LIM/Homeobox Protein Lhx1, MGC126723, MGC138141)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Frog, Human, Mouse, Rat
Form/Format
Supplied as a liquid in 0.02M PBS, pH 7.2, 0.1% sodium azide.
Purity/Purification
Purified
Purified
Specificity
Recognizes frog Lim-1. Does not crossreact with Lim-5 (the closest homolog of Lim-1 in frog) on tissue sections but does crossreact with Lim-5 in Western Blot and Immunoprecipitation.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
44,808 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (35294772..35301915). Location: 17q12
OMIM
601999
3D Structure
ModBase 3D Structure for P48742
Immunogen
Synthetic peptide corresponding to C-terminal portion of frog Lim-1.

Product Categories/Family for anti-LHX1 antibody

Antibodies; Abs to Transcription Factors; Homeobox (HOX)
Applications Tested/Suitable for anti-LHX1 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Application Notes for anti-LHX1 antibody
Suitable for use in Immunohistochemistry, Western Blot, Immunocytochemistry and Immunoprecipitation. Not suitable for Immunofluorescence.
Dilution: Immunohistochemistry (Paraffin): 1:200-1:1000 (Fish and whole mounts: 1:500) Recommended fixative MEMFA.
Western Blot: 1:3000-1:6000
Immunocytochemistry: 1:500 on P19 cell line
Immunoprecipitation: 1:200

Testing Data of anti-LHX1 antibody

Int. J. Dev. Biol. 42: 61 - 66 (1998) http://www.ijdb.ehu.es/web/paper.php?doi=9496787
Rabbit Anti-LHX1 Polyclonal Antibody – Cat# MBS611342

Other Notes

Small volumes of anti-LHX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LHX1 purchase

MBS611342 is an antibody targeting LHX1. Also known as Lim-1 (Homeobox Protein Lim1, LIM Homeobox Protein 1, LHX1, LIM/Homeobox Protein Lhx1, MGC126723, MGC138141). Reactive in Frog, Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LHX1. It may not necessarily be applicable to this product.

NCBI GI #
30410785
NCBI GeneID
3975
NCBI Accession #
NP_005559.2
UniProt Primary Accession #
P48742
UniProt Secondary Accession #
Q3MIW0
UniProt Related Accession #
P48742
GenBank Nucleotide #
NM_005568.3
NCBI Official Full Name
LIM/homeobox protein Lhx1
NCBI Official Synonym Full Names
LIM homeobox 1
NCBI Official Symbol
LHX1
NCBI Official Synonym Symbols
LIM1; LIM-1
UniProt Protein Name
LIM/homeobox protein Lhx1
UniProt Synonym Protein Names
Homeobox protein Lim-1
Protein Family
LIM/homeobox protein
UniProt Gene Name
LHX1
UniProt Synonym Gene Names
LIM-1; LIM1; LIM homeobox protein 1; hLim-1
UniProt Entry Name
LHX1_HUMAN
NCBI Protein Information
LIM/homeobox protein Lhx1; LIM homeobox protein 1; homeobox protein Lim-1

NCBI Summary for LHX1

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. [provided by RefSeq, Dec 2010]
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UniProt Comments for LHX1

LHX1: Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.

Protein type: Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: protein complex; nucleus

Molecular Function: zinc ion binding; sequence-specific DNA binding; transcription factor activity; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; motor axon guidance; forebrain regionalization; uterus development; embryonic pattern specification; pronephros development; post-embryonic development; anterior/posterior pattern formation; ectoderm formation; cell-cell signaling; ureteric bud development; anatomical structure formation; cerebellum development; kidney development; fallopian tube development; cervix development; nervous system development; anatomical structure morphogenesis; ventral spinal cord development; vagina development; embryonic viscerocranium morphogenesis; gastrulation with mouth forming second; somite rostral/caudal axis specification; pattern specification process; Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation; organ morphogenesis; telencephalon development; positive regulation of embryonic development; dorsal/ventral pattern formation; ureteric bud branching; regulation of gene expression; endoderm formation; embryonic retina morphogenesis in camera-type eye; cerebellar Purkinje cell differentiation; spinal cord association neuron differentiation; negative regulation of transcription, DNA-dependent; urogenital system development; anterior/posterior axis specification
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Research Articles on LHX1

1. study concludes that heterozygous mutations of LHX1 might be one cause of the Mayer-Rokitansky-Kuster-Hauser syndrome in a subgroup of patients

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LHX1 antibody

 Reference Product  PubMed Publications
 PAX2 antibody  >16 publications with LHX1 and PAX2
 LDB1 antibody  >16 publications with LHX1 and LDB1
 OTX2 antibody  >13 publications with LHX1 and OTX2
 LHX3 antibody  >10 publications with LHX1 and LHX3
 FOXA2 antibody  >8 publications with LHX1 and FOXA2
 ISL1 antibody  >5 publications with LHX1 and ISL1
 RLIM antibody  >5 publications with LHX1 and RLIM
 PTF1A antibody  >2 publications with LHX1 and PTF1A

Pathways associated with anti-LHX1 antibody

 Products by Pathway  Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram

Diseases associated with anti-LHX1 antibody

 Disease Name  Pubmed Publications
 Female Urogenital Diseases Antibodies  >12 publications with LHX1 and Female Urogenital Diseases
 Kidney Diseases Antibodies  >6 publications with LHX1 and Kidney Diseases
 Heart Diseases Antibodies  >2 publications with LHX1 and Heart Diseases
 Immune System Diseases Antibodies  >2 publications with LHX1 and Immune System Diseases
 Precancerous Conditions Antibodies  >2 publications with LHX1 and Precancerous Conditions
 Lymphoma Antibodies  >2 publications with LHX1 and Lymphoma
 Brain Diseases Antibodies  >2 publications with LHX1 and Brain Diseases
 Uterine Cervical Neoplasms Antibodies  >1 publications with LHX1 and Uterine Cervical Neoplasms
 Hypertension Antibodies  >1 publications with LHX1 and Hypertension
 Carcinoma, Hepatocellular Antibodies  >1 publications with LHX1 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-LHX1 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >49 publications with LHX1 and Embryonic Tissue
 Kidney Antibodies  >44 publications with LHX1 and Kidney
 Brain Antibodies  >43 publications with LHX1 and Brain
 Uterus Antibodies  >10 publications with LHX1 and Uterus
 Lung Antibodies  >2 publications with LHX1 and Lung
 Thyroid Antibodies  >2 publications with LHX1 and Thyroid
 Cervix Antibodies  >1 publications with LHX1 and Cervix
 Prostate Antibodies  >1 publications with LHX1 and Prostate
 Ovary Antibodies  >1 publications with LHX1 and Ovary
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