Rabbit Anti-ACCN4 Polyclonal Antibody – Cat# MBS611363

Acid Sensing Ion Channels 4 (ACCN4) Antibody – Rabbit Polyclonal

Name: ACCN4 Antibody; Polyclonal; Rabbit; Human/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS611363
Price: 965 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS611363

Tissue acidosis that occurs in ischemia, tissue damage or inflammation is accompanied by pain. Proton-gated cation channels are activated by low pH in nociceptive neurons. H+-gated channels are members of the NaC/DEG superfamily that include: (1)… More details

$965 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Acid Sensing Ion Channels 4 (ACCN4), Polyclonal Antibody

Full Product Name

Acid Sensing Ion Channels 4 (ASIC4)

Product Gene Name

anti-ACCN4 antibody

Product Synonym Names

Anti -Acid Sensing Ion Channels 4 (ASIC4)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Rat

Form/Format

Supplied as a liquid in 100mM Tris, pH 7.5, 0.2% BSA, 0.05% sodium azide, 40% glycerol.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human Acid Sensing Ion Channels 4 (ASIC4). No significant sequence homology is detected with other ASIC-beta or other ASICs.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

70,105 Da

Chromosome Location

Chromosome: 2; NC_000002.11 (220378892..220403494). Location: 2q35

OMIM

606715

3D Structure

ModBase 3D Structure for Q96FT7

Immunogen

Synthetic peptide 19aa sequence of human ASIC4 (KLH coupled). Location: ~N-terminal; Extracellular. Species Sequence Homology: Rat, mouse: 100%.

Product Categories/Family for anti-ACCN4 antibody

Antibodies; Abs to Ion Channel

Applications Tested/Suitable for anti-ACCN4 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-ACCN4 antibody

Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1-10ug/ml (ECL)
ELISA: 0.5-1ug/ml. Coat ELISA plates at 1ug/ml with Control Peptide.

Other Notes

Small volumes of anti-ACCN4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACCN4 purchase

MBS611363 is an antibody targeting ACCN4. Also known as Acid Sensing Ion Channels 4 (ASIC4). Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACCN4. It may not necessarily be applicable to this product.

NCBI GI #

256773230

NCBI GeneID

55515

NCBI Accession #

NP_878267.2

UniProt Primary Accession #

Q96FT7

UniProt Secondary Accession #

Q53SB7; Q6GMS1; Q6PIN9; Q9NQA4

UniProt Related Accession #

Q96FT7

GenBank Nucleotide #

NM_182847.2

NCBI Official Full Name

amiloride-sensitive cation channel 4 isoform 2

NCBI Official Synonym Full Names

amiloride-sensitive cation channel 4, pituitary

NCBI Official Symbol

ACCN4

NCBI Official Synonym Symbols

ASIC4; BNAC4; MGC17248; MGC24860

UniProt Protein Name

Amiloride-sensitive cation channel 4

UniProt Synonym Protein Names

Acid-sensing ion channel 4; ASIC4; Amiloride-sensitive cation channel 4, pituitary

UniProt Gene Name

ACCN4

UniProt Synonym Gene Names

ASIC4

UniProt Entry Name

ACCN4_HUMAN

NCBI Protein Information

amiloride-sensitive cation channel 4; OTTHUMP00000064871; OTTHUMP00000064872; brain sodium channel 4; acid-sensing ion channel 4

NCBI Summary for ACCN4

This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. Alternative splicing at this locus results in two transcript variants encoding different isoforms. [provided by RefSeq]

UniProt Comments for ACCN4

ASIC4: Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral; Channel, sodium; Transporter

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: integral to plasma membrane

Molecular Function: sodium ion transmembrane transporter activity; ion channel activity; sodium channel activity

Biological Process: transport

Research Articles on ACCN4

1. Data show that transfected ASIC4 is targeted to the plasma membrane in CHO-K1 cells, where it associates with ASIC1a and downregulates exogenous ASIC1a expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-ACCN4 antibody

Disease Name	Pubmed Publications
Seizures Antibodies	>1 publications with ACCN4 and Seizures
Epilepsy Antibodies	>1 publications with ACCN4 and Epilepsy

Organs/Tissues associated with anti-ACCN4 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with ACCN4 and Brain