Melanin Concentrating Hormone Receptor1 Antibody – Rabbit Polyclonal

The cyclic neuropeptide, Melanin-Concentrating Hormone (MCH), plays an important role in food intake and energy balance. MCH stimulates feeding. it is up regulated in obese mice and during fasting. Animals lacking MCH eat less and are leaner. A receptor for MCH (MCHR) has been cloned. Human MCH receptor is 402aa membrane protein described as an orphan G-protein coupled receptor SLC-1 or GPR24, somatostatin receptor-like protein. It has 7 transmembrane domains, a Dry motif at the boundary of TM3 and the 2nd intracellular loop, a consensus site for N-linked glycosylation at the N-terminus. MCHR is expressed in ventromedial and dorsomedial nuclei of the hypothalamus. An orphan G-protein coupled receptor (SLC-1, GPR24) has been identified as the receptor of MCH. MCH receptor (MCH1R; human 402aa, rat 353aa) is predicted to contain 7 transmembrane domains. Moderate levels of MCHR are also found in eye and skeletal muscle, tongue and pituitary. MCHR binds MCH with sub-nanomolar affinity. It is stimulated by MCH to mobilize intracellular Ca2+ and reduce forskolin-elevated cAMP levels. A second human MCH receptor (MCH2R) has been cloned and characterized. MCH2R gene encodes a 340aa protein with 38% identity with MCH1R. It has the basic characteristics of GPCR and belongs to class 1 GPCR superfamily. MCH2R transfected cells responds to MCH with an increase in intracellular Ca2+ levels and increased cellular extrusion of protons.

Small volumes of anti-Melanin Concentrating Hormone Receptor1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS611370 is an antibody targeting Melanin Concentrating Hormone Receptor1. Also known as Melanin Concentrating Hormone Receptor1 (MCHR1). Reactive in Human. Host: Rabbit.