Atpase, Ca, Autoinhibitory Domain Antibody – Rabbit Polyclonal

Ca2+ plays a critical role in intracellular signaling. Intracellular Ca2+ levels are tightly controlled by continuos removal of Ca2+ via ATP-driven Ca2+ pump in the endoplasmic reticulum and plasma membrane, and Ca2+ transport system, the Na+/Ca2+ exchangers (NCX), in the plasma membrane. NCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In most cells, 3 Na+ are exchanged for 1 Ca2+. In mammals, at least 5 distinct genes code for the exchangers: Three NCX (NCX1, NCX2, and NCX3), and two in the NCKX family (NCKX1 and NCKX2). The N-terminal signal peptide is cleaved off from the mature exchanger protein. NCX contains a highly basic region in the large hydrophilic, intracellular loop called XIP (Exchange inhibitory peptide; RRLLFYKYVYKRYRAGKQRG 20 aa), that inhibits Na-Ca+ exchange in cardiac sarcolemmal vesicles and in other cells. Little or no sequence identity is found between the NCX and the Ca-pump. However, XIP also inhibits the Ca pumps with more or less same efficiency as C28R2 peptide sequence (LRRGQILWFRGLNRIQTQIRVVKAFRSS, 28 aa) corresponding to the autoinhibitory domain of Ca-pump.

• 1). Street VA et al (1998) Nat. Genet. 19, 390; Heim R et al (1992) Eur. J. Biochem. 205, 330; Brandt P et al (1992) Genomics 14, 484; Latif F et al (1993) Cancer Res. 53, 861; Keeton TP et al (1995) Biochem. J. 306, 779; shull GE et al (1988) J Biol. Chem. 263, 8646; Brown BJ et al (1996) BBA 1283, 10; Hale CC et al (1997) BBRC 236, 113; Xu W et al (1997) Arch. Biochem. Biophys. 341, 273; Blaustein MP and Lederer J (1999) Physiol Rev. 79, 763-854 (review).

Small volumes of anti-ATPase, Ca, Autoinhibitory Domain antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS611415 is an antibody targeting ATPase, Ca, Autoinhibitory Domain. Also known as Anti - ATPase, Ca, Autoinhibitory Domain (c28r2). Reactive in Human, Mouse, Rat. Host: Rabbit
Source: Human.