Hydroxysteroid Dehydrogenase, 11-Beta, Type II Antibody – Rabbit Polyclonal

11 beta-HSD2 plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11 beta-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess. 11 beta-HSD2 mRNA and protein are expressed in placenta and mineralocorticoid target tissues, particularly the kidney. In mouse, expression of this enzyme is tissue-specific and developmentally regulated, indicating the importance of the enzyme in controlling glucocorticoid- mediated maturation.

Small volumes of anti-Hydroxysteroid Dehydrogenase, 11-beta, Type II antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS611585 is an antibody targeting Hydroxysteroid Dehydrogenase, 11-beta, Type II. Also known as Hydroxysteroid Dehydrogenase, 11-beta, Type II (11b-HSD2). Reactive in Human, Mouse, Rat. Host: Rabbit.