SH2B2 Antibody – Rabbit Polyclonal

APS: an adapter protein involved in coupling immunoreceptors to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. Interacts with several proteins including KIT/c-KIT, SHC, GRB2, EPOR, CBL/c-CBL, PDGFR, VAV1 and VAV3. Interacts with SHC through its N-terminal region, with GRB2 via the phosphorylated C-terminus and with EPOR and KIT via its SH2 domain. Interacts with GRB2 after B-cell antigen receptor stimulation. Interacts with VAV3 via its PH domain, inducing cytoskeletal reorganization. Expressed in spleen, prostrate, testis, uterus, small intestine and skeletal muscle. Among haematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines. Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex.

Protein type: Adaptor/scaffold

Cellular Component: ruffle; membrane; cytoplasm; plasma membrane; stress fiber; actin filament

Molecular Function: identical protein binding; protein binding; signal transducer activity; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity; JAK pathway signal transduction adaptor activity

Biological Process: regulation of Ras protein signal transduction; antigen receptor-mediated signaling pathway; nervous system development; regulation of immune response; negative regulation of glucose import; regulation of JAK-STAT cascade; positive regulation of signal transduction; cytokine and chemokine mediated signaling pathway; B-1 B cell homeostasis; insulin receptor signaling pathway; brown fat cell differentiation; regulation of metabolic process; glucose homeostasis; actin cytoskeleton organization and biogenesis