Rabbit Anti-FBXO17 Polyclonal Antibody – Cat# MBS611725

Western Blot of MBS611725 performed from 30ug of recombinant full length FBG4. MBS611725 (1:500 dilution) was incubated O/N at 4°C. Secondary rabbit HRP antibody was incubated 1 hour at RT followed by ECL detection.

FBXO17 Antibody – Rabbit Polyclonal

Name: FBXO17 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS611725
Price: 665 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS611725

F-box proteins, a critical component of the evolutionary conserved ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box), recruit substrates for ubiquitination and consequent degradation through their specific protein-protein interaction domains.… More details

$665 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FBG4 (FBXO17), Polyclonal Antibody

Full Product Name

FBG4 (F-box 4)

Product Gene Name

anti-FBXO17 antibody

Product Synonym Names

Anti -FBG4 (F-box 4)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Residues with residues 70-85 (LQLARDRSAEGRALYA) of the human FBG4 protein. Crossreacts with mouse and rat FBG4 (100% sequence identity).

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20 degree C or colder. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

31,479 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (39432041..39466453, complement). Location: 19q13.2

OMIM

609094

3D Structure

ModBase 3D Structure for Q96EF6

Product Categories/Family for anti-FBXO17 antibody

Antibodies; Abs to Ubiquitin Ligases

Applications Tested/Suitable for anti-FBXO17 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-FBXO17 antibody

Western Blot: Use at 1:500 to 1:1000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Other Notes

Small volumes of anti-FBXO17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FBXO17 purchase

MBS611725 is an antibody targeting FBXO17. Also known as FBG4 (F-box 4). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FBXO17. It may not necessarily be applicable to this product.

NCBI GI #

22325388

NCBI GeneID

115290

NCBI Accession #

NP_680474.1

UniProt Primary Accession #

Q96EF6

UniProt Secondary Accession #

Q96LQ4

UniProt Related Accession #

Q96EF6

GenBank Nucleotide #

NM_148169.2

NCBI Official Full Name

F-box only protein 17 isoform 1

NCBI Official Synonym Full Names

F-box protein 17

NCBI Official Symbol

FBXO17

NCBI Official Synonym Symbols

FBG4; FBX26; Fbx17; FBXO26

UniProt Protein Name

F-box only protein 17

UniProt Synonym Protein Names

F-box only protein 26

Protein Family

F-box only protein

UniProt Gene Name

FBXO17

UniProt Synonym Gene Names

FBG4; FBX17; FBX26; FBXO26

UniProt Entry Name

FBX17_HUMAN

NCBI Protein Information

F-box only protein 17; F-box protein FBG4; F-box only protein 26

NCBI Summary for FBXO17

This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

UniProt Comments for FBXO17

FBXO17: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex- type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: SCF ubiquitin ligase complex

Molecular Function: protein binding; glycoprotein binding

Research Articles on FBXO17

1. the apparent occurrence of an unusual TG 3' splice site in intron 3 is discussed

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FBXO17 antibody

Reference Product	PubMed Publications
FBXO6 antibody	>1 publications with FBXO17 and FBXO6
RBX1 antibody	>1 publications with FBXO17 and RBX1
FBXO27 antibody	>1 publications with FBXO17 and FBXO27
SKP1 antibody	>1 publications with FBXO17 and SKP1

Pathways associated with anti-FBXO17 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies	Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies	Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Selenium Metabolism And Selenoproteins Pathway antibodies	Selenium Metabolism And Selenoproteins Pathway Diagram

Diseases associated with anti-FBXO17 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1 publications with FBXO17 and Neoplasms