Rabbit Anti-SARM1 Polyclonal Antibody – Cat# MBS611757

SARM1 / SARM (2ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human tonsil, followed by biotinylated goat rabbit IgG secondary, alkaline phosphatase-streptavidin and chromogen.

SARM1 Antibody – Rabbit Polyclonal

Name: SARM1 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS611757
Price: 800 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS611757

MBS611757 is an antibody targeting SARM1. Also known as SARM1 (Sterile alpha and TIR motif containing 1). Reactive in Human, Mouse. Host: Rabbit. More details

$800 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SARM1, Polyclonal Antibody

Full Product Name

SARM1 (Sterile alpha and TIR motif containing 1)

Product Gene Name

anti-SARM1 antibody

Product Synonym Names

Anti -SARM1 (Sterile alpha and TIR motif containing 1)

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS, 0.02% sodium azide.

Purity/Purification

Highly Purified
Purified by Ion Exchange chromatography.

Specificity

Recognizes Human Sterile Alpha And TIR Motif Containing 1 (SARM1/KIAA0524). Species Crossreactivity: Human, Mouse.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

79,388 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (26698987..26728065). Location: 17q11

OMIM

607732

3D Structure

ModBase 3D Structure for Q6SZW1

Immunogen

Synthetic peptide, KLH-conjugated. Epitope: peptide corresponding to amino acids near the C-terminus of human SARM

Product Categories/Family for anti-SARM1 antibody

Antibodies; Abs to Toll Like Receptors (TLR)

Applications Tested/Suitable for anti-SARM1 antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Application Notes for anti-SARM1 antibody

Suitable for use in Immunocytochemistry, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry: 2ug/ml
Western Blot: 0.5-2ug/ml

Other Notes

Small volumes of anti-SARM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SARM1. It may not necessarily be applicable to this product.

NCBI GI #

154090976

NCBI GeneID

23098

NCBI Accession #

NP_055892.2

UniProt Primary Accession #

Q6SZW1

UniProt Secondary Accession #

O60277; Q7LGG3; Q9NXY5

UniProt Related Accession #

Q05B42; Q0D2N8; Q6SZW1

GenBank Nucleotide #

NM_015077.2

NCBI Official Full Name

sterile alpha and TIR motif-containing protein 1

NCBI Official Synonym Full Names

sterile alpha and TIR motif containing 1

NCBI Official Symbol

SARM1

NCBI Official Synonym Symbols

SARM; SAMD2; FLJ36296; KIAA0524

UniProt Protein Name

Sterile alpha and TIR motif-containing protein 1

UniProt Synonym Protein Names

Sterile alpha and Armadillo repeat protein; Sterile alpha motif domain-containing protein 2; SAM domain-containing protein 2; Tir-1 homolog

Protein Family

Sterile alpha and TIR motif-containing protein

UniProt Gene Name

SARM1

UniProt Synonym Gene Names

KIAA0524; SAMD2; SARM

UniProt Entry Name

SARM1_HUMAN

NCBI Protein Information

sterile alpha and TIR motif-containing protein 1; tir-1 homolog; OTTHUMP00000163322; SAM domain-containing protein 2; sterile alpha and Armadillo repeat protein; sterile alpha motif domain-containing protein 2; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila

UniProt Comments for SARM1

SARM1: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q11

Cellular Component: microtubule; mitochondrion; axon; cytoplasm; dendrite; extrinsic to mitochondrial outer membrane; synapse; cytosol; cell junction

Biological Process: regulation of apoptosis; MyD88-independent toll-like receptor signaling pathway; regulation of dendrite morphogenesis; response to glucose stimulus; toll-like receptor signaling pathway; innate immune response; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway

Research Articles on SARM1

1. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SARM1 antibody

Disease Name	Pubmed Publications
Colorectal Neoplasms Antibodies	>1 publications with SARM1 and Colorectal Neoplasms

Organs/Tissues associated with anti-SARM1 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>3 publications with SARM1 and Kidney
Brain Antibodies	>2 publications with SARM1 and Brain
Eye Antibodies	>1 publications with SARM1 and Eye