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Sex Hormone Binding Globulin (SHBG) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS611774

MBS611774 is an antibody targeting SHBG. Also known as Sex Hormone Binding Globulin, Human (SHBG, TEBG). Reactive in Human. Host: Goat. More details

$610 / 1000 Tests +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Sex Hormone Binding Globulin (SHBG), Polyclonal Antibody
Full Product Name
Sex Hormone Binding Globulin, Human (SHBG, TEBG)
Product Gene Name
Product Synonym Names
Anti -Sex Hormone Binding Globulin, Human (SHBG, TEBG)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid, 0.05% sodium azide, before the addition of glycerol to 40%.
Purity/Purification
Serum
Serum
Specificity
Recognizes human SHBG.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
43,779 Da
Chromosome Location
chromosome: 17; Location: 17p13-p12
OMIM
182205
3D Structure
ModBase 3D Structure for P04278
Immunogen
Human Sex Hormone Binding Globulin.

Product Categories/Family for anti-SHBG antibody

Applications Tested/Suitable for anti-SHBG antibody
ELISA (EL/EIA), Western Blot (WB), Radioimmunoassay (RIA)
Application Notes for anti-SHBG antibody
Suitable for use in RIA, ELISA and Western Blot.

Other Notes

Small volumes of anti-SHBG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SHBG. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
sex hormone-binding globulin
NCBI Official Synonym Full Names
sex hormone-binding globulin
NCBI Official Symbol
SHBG
NCBI Official Synonym Symbols
ABP; SBP; TEBG; MGC126834; MGC138391; SHBG
UniProt Protein Name
Sex hormone-binding globulin
UniProt Synonym Protein Names
Sex steroid-binding protein; SBP; Testis-specific androgen-binding protein; ABP; Testosterone-estradiol-binding globulin; TeBG; Testosterone-estrogen-binding globulin
UniProt Gene Name
SHBG
UniProt Entry Name
SHBG_HUMAN
NCBI Protein Information
sex hormone-binding globulin; androgen binding protein; sex steroid-binding protein; testosterone-binding beta-globulin; testosterone-estrogen-binding globulin; testosterone-estradiol-binding globulin; testis-specific androgen-binding protein

NCBI Summary for SHBG

This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for SHBG

SHBG: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: extracellular region

Molecular Function: androgen binding

Biological Process: primary spermatocyte growth
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Research Articles on SHBG

1. SHBG, CBG and total cortisol and free plasma cortisol were measured and to investigate whether or not these analytes correlated with the degree of insulin resistance and the presence of the metabolic syndrome.
2. genetic variants of SHBG may influence SHBG levels and in part contribute to the phenotypic expression of human diseases (Review)
3. SHBG levels were positively associated with cortical bone size, independently from sex-steroid levels
4. involvement of SHBG and SHBG polymorphisms in the definition of breast cancer risk; action of SHBG in breast cancer cells including inhibition of several effects of estradiol in breast cancer cells [review]
5. Higher SHBG levels reduce the risk of type 2 diabetes.
6. Circulating NT-proBNP levels are positively associated with sex hormone-binding globulin levels in non-obese peri- and postmenopausal women.
7. The opposing effects of estrogens and testosterone on the immune system and imbalance in the levels of these hormones in systemic lupus erythematosus patients can be enhanced by the SHBG327Asn protein variant.
8. Reference intervals were calculated for male testosterone, SHBG, FSH and LH in serum from 599 individuals.
9. sex hormone-binding globulin (SHBG) levels are related to a decrease in High-density lipoprotein cholesterol and apolipoprotein A-I levels during puberty in boys and to a decrease in triglyceride levels during puberty in both sexes
10. Although the concentration of SHBG does not change in fetus when pregnant woman is complicated with gestational diabetes, it is already influenced by the fetal regulation on hyperinsulinemia.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SHBG antibody

Pathways associated with anti-SHBG antibody

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