Goat Anti-SKAP2 Polyclonal Antibody – Cat# MBS611804

Detection of Human SKAP55 by Western Blot.

Src Kinase-Associated Phosphoprotein (SKAP2) Antibody – Goat Polyclonal

Name: SKAP2 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS611804
Price: 1090 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS611804

Src kinase-associated phosphoprotein of 55 kD (SKAP55) is an adaptor protein expressed exclusively in mononuclear cells of hematopoietic lineage, with preferential expression in T lymphocytes and monocytes. Also known as SCAP1, SKAP55 regulates… More details

$1090 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Src kinase-associated phosphoprotein (SKAP2), Polyclonal Antibody

Full Product Name

Src kinase-associated phosphoprotein (SKAP55)

Product Gene Name

anti-SKAP2 antibody

Product Synonym Names

Anti -Src kinase-associated phosphoprotein (SKAP55)

Clonality

Polyclonal

Isotype

IgG

Host

Goat

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol, 0.02% SODIUM AZIDE.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human SKAP55.

Preparation and Storage

Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

41,217 Da

Chromosome Location

Chromosome: 7; NC_000007.13 (26697397..27034862, complement). Location: 7p15.2

OMIM

605215

3D Structure

ModBase 3D Structure for O75563

Immunogen

E. coli-derived full-length recombinant human SKAP55 (aa1-358) Accession # Q86WV1

Product Categories/Family for anti-SKAP2 antibody

Antibodies; Abs to Protein Kinases

Applications Tested/Suitable for anti-SKAP2 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-SKAP2 antibody

Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1ug/ml

Other Notes

Small volumes of anti-SKAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SKAP2 purchase

MBS611804 is an antibody targeting SKAP2. Also known as Src kinase-associated phosphoprotein (SKAP55). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for SKAP2. It may not necessarily be applicable to this product.

NCBI GI #

16753212

NCBI GeneID

8935

NCBI Accession #

NP_003921.2

UniProt Primary Accession #

O75563

UniProt Secondary Accession #

Q53GP6; Q75MK6; Q75MZ4; Q9UBZ3; Q9UED8; A4D173

UniProt Related Accession #

O75563

GenBank Nucleotide #

NM_003930.3

NCBI Official Full Name

src kinase-associated phosphoprotein 2

NCBI Official Synonym Full Names

src kinase associated phosphoprotein 2

NCBI Official Symbol

SKAP2

NCBI Official Synonym Symbols

PRAP; RA70; SAPS; SCAP2; SKAP55R; SKAP-HOM

UniProt Protein Name

Src kinase-associated phosphoprotein 2

UniProt Synonym Protein Names

Pyk2/RAFTK-associated protein; Retinoic acid-induced protein 70; SKAP55 homolog; SKAP-55HOM; SKAP-HOM; Src family-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein; Src-associated adapter protein with PH and SH3 domains

Protein Family

Src kinase-associated phosphoprotein

UniProt Gene Name

SKAP2

UniProt Synonym Gene Names

PRAP; RA70; SAPS; SCAP2; SKAP55R; SKAP-55HOM; SKAP-HOM

UniProt Entry Name

SKAP2_HUMAN

NCBI Protein Information

src kinase-associated phosphoprotein 2; SKAP-55HOM; SKAP55 homolog; Pyk2/RAFTK-associated protein; src-associated adaptor protein; retinoic acid-induced protein 70; src family associated phosphoprotein 2; src family-associated phosphoprotein 2; Fyn-associated phosphoprotein SKAP55 homologue; src-associated adapter protein with PH and SH3 domains; src kinase-associated phosphoprotein 55-related protein; src kinase-associated phosphoprotein of 55-related protein

NCBI Summary for SKAP2

The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation. [provided by RefSeq, Jul 2008]

UniProt Comments for SKAP2

RA70: an ubiquitous adapter protein thought to play a role in the src signaling pathway. Contains a coiled-coil domain, a pleckstrin homology domain, and a SH3 domain. The SH3 domain binds to the proline-rich domain of Pyk2, inhibiting alpha-synuclein tyrosine phosphorylation. Can be phosphorylated by Src family kinases but not by Pyk2. Functions as a downstream target for Pyk2 and plays a role in alpha-synuclein phosphorylation. Negatively regulates alpha-synuclein phosphorylation following cell stress.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; SH3/SH2 adaptor activity

Biological Process: negative regulation of cell proliferation; positive regulation of signal transduction; B cell activation; protein complex assembly; signal transduction

Research Articles on SKAP2

1. results suggest that SKAP2 negatively regulates cell migration and tumor invasion in fibroblasts and glioblastoma cells by suppressing actin assembly induced by the WAVE2-cortactin complex

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SKAP2 antibody

Reference Product	PubMed Publications
PTPN22 antibody	>1 publications with SKAP2 and PTPN22

Pathways associated with anti-SKAP2 antibody

Products by Pathway	Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Signal Regulatory Protein (SIRP) Family Interactions Pathway antibodies	Signal Regulatory Protein (SIRP) Family Interactions Pathway Diagram

Diseases associated with anti-SKAP2 antibody

Disease Name	Pubmed Publications
Pancreatic Neoplasms Antibodies	>1 publications with SKAP2 and Pancreatic Neoplasms
Adenocarcinoma Antibodies	>1 publications with SKAP2 and Adenocarcinoma
Neoplasms Antibodies	>1 publications with SKAP2 and Neoplasms

Organs/Tissues associated with anti-SKAP2 antibody

Organ/Tissue Name	Pubmed Publications
Bone Marrow Antibodies	>1 publications with SKAP2 and Bone Marrow
Brain Antibodies	>1 publications with SKAP2 and Brain