Biliverdin Reductase (bvdR) Antibody – Rabbit Polyclonal

Cleavage of heme b (Fe-protoporphyrin IX) at the alpha-methene carbon bridge to form the open tetrapyrrole, biliverdin IXalpha and carbon monoxide (CO) is catalyzed by heme oxygenase (HO) isozymes HO-1 and HO-2 (heme hydrogen-donor: oxygen oxidoreductase; EC 1.14.99.3). In mammalian species biliverdin reductase (BVR; bilirubin: NAD(P)+ oxidoreductase; EC 1.3.1.24) converts the open tetrapyrrole to bilirubin. This pathway is the only efficient way of making bilirubin and hence deterring activation of oxygen by the heme molecule. The two isozymes of heme oxygen, one of which is referred to as HO-1, is a member of the heat shock protein family (Hsp32), and the second, or HO-2, is a constitutive form and is expressed at exceedingly high levels in the brain and testes. The end products of the heme degradation process have important physiological activities. CO is suspected of being a potential messenger in the brain and systemic organs wherein by interacting with the heme-dependent form of guanylate cyclase it stimulates cGMP-production. Bile pigments have been demonstrated to display potent antioxidant activity and have effective antiviral activity against HIV and herpes virus. BVR is unique among all enzymes characterized to date in having two pH optima (6.8 and 8.7), using a different cofactor at each pH range (NADH at pH 7.0 and NADPH at pH 8.7). The enzyme displays pI and molecular mass microheterogeneity which appear to be a result of post translational modifications. In rat the enzyme also shows a tissue specific developmental pattern. BVR is not a inactivated by heat shock and its preexisting message is not sequestered from translation subsequent to thermal stress.

Small volumes of anti-bvdR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS611818 is an antibody targeting bvdR. Also known as Biliverdin Reductase. Reactive in Hamster, Human, Porcine, Rat. Host: Rabbit.