Guanine Nucleotide Dissociation Inhibitor (PAS_chr1-4_0063) Antibody – Rabbit Polyclonal

Small molecular weight GTP-binding proteins of the Rab family have been shown to play an essential role in the regulation of vesicular trafficking. The cycling of these proteins between the inactive (GDP-bound) and active (GTP-bound) forms is thought to catalyze docking to specific target membranes. To date, several accessory proteins which serve to regulate the association of Rab proteins with GTP or GDP have been identified(4,5,6). The best characterized of these Rab accessory proteins is Rab3A GDI(4,5,7,8). Rab3A GDI forms cytosolic complexes with Rab3A and, in vitro, promotes the dissociation of Rab3A from membranes(7,8). Two other isoforms of GDI have recently been isolated and have been termed GDI b and GDI-2, respectively(3,5). Studies have revealed that the proportion of Rab proteins found associated with a particular GDI isoform depends upon the abundance of the specific GDI in the cytosol, as well as on the tissue and cell type examined(5,6,7).

Small volumes of anti-PAS_chr1-4_0063 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS611886 is an antibody targeting PAS_chr1-4_0063. Also known as Guanine Nucleotide Dissociation Inhibitor (GDI). Reactive in Bovine, Human, Mouse, Rat. Host: Rabbit.