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SLC4A7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS611906

Bicarbonate, along with CO2, is the major pH buffer of biological fluids. A great majority of HCO3- reabsorption occurs via trans-cellular coupling of the luminal Na-H+ exchanger 3 and Na+-H+ ATPase with the basolateral Na+ HCO3- cotransporters (NBC). Several… More details

$965 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NBC2 (Slc4a7), Polyclonal Antibody
Full Product Name
NBC2 (HCO3 Cotransporters 2)
Product Gene Name
anti-Slc4a7 antibody
Product Synonym Names
Anti -NBC2 (HCO3 Cotransporters 2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, before the addition of glycerol to 40%.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human NBC2. No significant sequence homology was found with NBC1 or NBC3. Species sequence homology: rat-100%.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
135,954 Da
Chromosome Location
Chromosome: 15; NC_005114.2 (12071975..12125840, complement). Location: 15p16
3D Structure
ModBase 3D Structure for Q9R1N3
Immunogen
A 20aa peptide sequence within the cytoplasmic, C-terminus of human NBC2 (KLH).

Product Categories/Family for anti-Slc4a7 antibody

Antibodies; Abs to Ion Transport
Applications Tested/Suitable for anti-Slc4a7 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Slc4a7 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1-10ug/ml using Chemiluminescence technique.
ELISA: 1:5000-1:50,000 using 50-100ng of control peptide/well.

Other Notes

Small volumes of anti-Slc4a7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Slc4a7 purchase

MBS611906 is an antibody targeting Slc4a7. Also known as NBC2 (HCO3 Cotransporters 2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Slc4a7. It may not necessarily be applicable to this product.

NCBI GI #
5669564
NCBI GeneID
117955
UniProt Primary Accession #
Q9R1N3
UniProt Secondary Accession #
Q9QYD5; Q9R1L1
UniProt Related Accession #
Q9R1N3
NCBI Official Full Name
NBC-like protein 2
NCBI Official Synonym Full Names
solute carrier family 4, sodium bicarbonate cotransporter, member 7
NCBI Official Symbol
Slc4a7
NCBI Official Synonym Symbols
NBC3; NBCn1
UniProt Protein Name
Sodium bicarbonate cotransporter 3
UniProt Synonym Protein Names
Electroneutral sodium bicarbonate cotransporter 1; NBC-like protein; Solute carrier family 4 member 7
Protein Family
Sodium bicarbonate cotransporter
UniProt Gene Name
Slc4a7
UniProt Synonym Gene Names
Nbc; Nbc2; Nbc3; Nbcn1
UniProt Entry Name
S4A7_RAT
NCBI Protein Information
sodium bicarbonate cotransporter 3; NBC-like protein; solute carrier family 4 member 7; electroneutral sodium bicarbonate cotransporter 1

NCBI Summary for Slc4a7

regulates intracellular pH in different cells along with Na+-driven HCO3- transporters, the Na+-driven Cl-/HCO3- exchanger [RGD]

UniProt Comments for Slc4a7

SLC4A7: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. Belongs to the anion exchanger (TC 2.A.31) family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Cellular Component: stereocilium; integral to plasma membrane; basolateral plasma membrane; cytoplasm; apical plasma membrane; plasma membrane; integral to membrane; synapse; cytoplasmic vesicle

Molecular Function: inorganic anion exchanger activity; sodium:bicarbonate symporter activity

Biological Process: cochlear nucleus development; visual perception; bicarbonate transport; regulation of intracellular pH; auditory receptor cell development; retinal cell programmed cell death
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Research Articles on Slc4a7

1. The electroneutral sodium bicarbonate co-transporter SLC4A7 localizes in mitochondria and suppresses the ischaemia-induced activation of the mitochondrial pathway of apoptosis in coronary endothelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Slc4a7 antibody

 Products by Pathway  Pathway Diagram
 Bicarbonate Transporters Pathway antibodies  Bicarbonate Transporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with anti-Slc4a7 antibody

 Disease Name  Pubmed Publications
 Acidosis Antibodies  >9 publications with Slc4a7 and Acidosis
 Skin Diseases Antibodies  >5 publications with Slc4a7 and Skin Diseases
 Neoplasms Antibodies  >5 publications with Slc4a7 and Neoplasms
 Breast Neoplasms Antibodies  >5 publications with Slc4a7 and Breast Neoplasms
 Congenital Abnormalities Antibodies  >3 publications with Slc4a7 and Congenital Abnormalities
 Drug Toxicity Antibodies  >2 publications with Slc4a7 and Drug Toxicity
 Kidney Diseases Antibodies  >2 publications with Slc4a7 and Kidney Diseases
 Neurodegenerative Diseases Antibodies  >1 publications with Slc4a7 and Neurodegenerative Diseases
 Myocardial Ischemia Antibodies  >1 publications with Slc4a7 and Myocardial Ischemia
 Nervous System Malformations Antibodies  >1 publications with Slc4a7 and Nervous System Malformations

Organs/Tissues associated with anti-Slc4a7 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >23 publications with Slc4a7 and Kidney
 Brain Antibodies  >12 publications with Slc4a7 and Brain
 Eye Antibodies  >2 publications with Slc4a7 and Eye
 Prostate Antibodies  >1 publications with Slc4a7 and Prostate
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