RAD54L Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.

RAD54L: Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments. May play also an essential role in telomere length maintenance and telomere capping in mammalian cells. Belongs to the SNF2/RAD54 helicase family.

Protein type: Helicase; EC 3.6.4.-; EC 3.6.1.-; Cell cycle regulation; DNA repair, damage

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; DNA binding; helicase activity; ATP binding

Biological Process: response to drug; meiosis; DNA strand renaturation; response to ionizing radiation; DNA repair; chromosome organization and biogenesis; double-strand break repair via homologous recombination; DNA recombination

Disease: Lymphoma, Non-hodgkin, Familial; Breast Cancer