Isofagomine D-tartrate

Isofagomine (D-tartrate) is a competitive inhibitor of human lysosomal Beta-glucosidase (Ki = 0.016-0.025uM; IC50 = 0.06uM). 1 By interacting with the catalytic pocket of Beta-glucosidase it acts as a chemical chaperone that fibroblasts. 1 increases the amount of Beta-glucosidase by stabilizing and/or promoting the folding of the enzyme. 2 Isofagomine (D-tartrate) has been shown to increase lysosomal Beta-glucosidase activity by 2 to 3-fold in mutant N370S Gaucher. This compound has been studied in the context of Gaucher disease, a lysosomal storage disorder resulting from substantial deficiency of Beta-glucosidase and recently identified as a parkinsonism risk factor.

Small volumes of Isofagomine D-tartrate biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6120670 is a biochemical targeting Isofagomine D-tartrate. Host: Synthetic.