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PARK8 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6121397

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PARK8, Monoclonal Antibody
Full Product Name
PARK8 (LRRK2) (LRRK2, PARK8, Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin) (FITC)
Product Gene Name
Product Synonym Gene Name
LRRK2
Product Synonym Names
LRRK2; PARK8; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin
Clonality
Monoclonal
Isotype
IgG1
Clone Number
133AT720
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein isothiocyanate (FITC).
Purity/Purification
Purified by Protein G Affinity Chromatography
Specificity
Recognizes human LRRK2. Species crossreactivity: mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
2527
Chromosome Location
Chromosome: 12; NC_000012.11 (40618813..40763087). Location: 12q12
OMIM
168600
3D Structure
ModBase 3D Structure for Q5S007
Immunogen
Purified, His-tagged recombinant protein comprised of the C-terminal 261 residues of human LRRK2 (Q5S007).
Conjugate
FITC
Special Handling
Light sensitive

Product Categories/Family for anti-PARK8 antibody

Applications Tested/Suitable for anti-PARK8 antibody
FLISA, Western Blot (WB)
Application Notes for anti-PARK8 antibody
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-PARK8 antibody

Western Blot analysis of mouse brain cell lysate using.
Mouse Anti-PARK8 Monoclonal Antibody – Cat# MBS6121397

Product References and Citations for anti-PARK8 antibody

1. Olfactory heterogeneity in LRRK2 related Parkinsonism. Silveira-Moriyama L, et al. Mov Disord, 2010 Sep 3. PMID 20818658. 2. LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease. Saunders-Pullman R, et al. Mov Disord, 2010 Sep 3. PMID 20818610. 3. Low frequency of common LRRK2 mutations in Mexican patients with Parkinson's disease. Yescas P, et al. Neurosci Lett, 2010 Aug 18. PMID 20727385. 4. Absence of Commonly Reported Leucine-Rich Repeat Kinase 2 Mutations in Eastern Indian Parkinson's Disease Patients. Sanyal J, et al. Genet Test Mol Biomarkers, 2010 Aug 19. PMID 20722494. 5. Penetrance in Parkinson's disease related to the LRRK2 R1441G mutation in the Basque country (Spain). Ruiz-Martinez J, et al. Mov Disord, 2010 Aug 18. PMID 20721916.

Other Notes

Small volumes of anti-PARK8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PARK8 purchase

MBS6121397 is an antibody targeting PARK8. Also known as PARK8 (LRRK2) (LRRK2, PARK8, Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin) (FITC). Reactive in Human, Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PARK8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
leucine-rich repeat serine/threonine-protein kinase 2
NCBI Official Synonym Full Names
leucine-rich repeat kinase 2
NCBI Official Symbol
LRRK2
NCBI Official Synonym Symbols
PARK8; RIPK7; ROCO2; AURA17; DARDARIN
UniProt Protein Name
Leucine-rich repeat serine/threonine-protein kinase 2
UniProt Synonym Protein Names
Dardarin
UniProt Gene Name
LRRK2
UniProt Synonym Gene Names
PARK8
UniProt Entry Name
LRRK2_HUMAN
NCBI Protein Information
leucine-rich repeat serine/threonine-protein kinase 2; augmented in rheumatoid arthritis 17

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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