• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ELAVL1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6121666

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ELAVL1, Monoclonal Antibody
Full Product Name
ELAVL1 (ELAVL1, HUR, ELAV-like protein 1, Hu-antigen R) (PE)
Product Gene Name
anti-ELAVL1 antibody
Product Synonym Names
ELAVL1; HUR; ELAV-like protein 1; Hu-antigen R
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
224CT6.5.3
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein G Affinity Chromatography
Specificity
Recognizes human ELAVL1.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Do not freeze R-Phycoerythrin conjugates. Light sensitive.
Molecular Weight
36,092 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (8023457..8070529, complement). Location: 19p13.2
OMIM
603466
3D Structure
ModBase 3D Structure for Q15717
Immunogen
Recombinant protein corresponding to ELAVL1 (Q15717)
Conjugate
PE
Special Handling
Light sensitive

Product Categories/Family for anti-ELAVL1 antibody

Antibodies; Actin Related Proteins
Applications Tested/Suitable for anti-ELAVL1 antibody
FLISA, Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-ELAVL1 antibody
FLISA: 1:1000
IF: 1:10-50
WB: 1:100-1000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ELAVL1 antibody

Western Blot analysis in Jurkat cell line lysates (35ug/lane) using.This demonstrates the ELAVL1/MB10217 antibody detected the ELAVL1/MB10217 protein (arrow).
Mouse Anti-ELAVL1 Monoclonal Antibody – Cat# MBS6121666

Immunofluorescence (IF) of anti-ELAVL1 antibody

Confocal immunofluorescent analysis of NCI-H460 cell using followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).
Mouse Anti-ELAVL1 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS6121666

Product References and Citations for anti-ELAVL1 antibody

Tholanikunnel, B.G., et al. J. Biol. Chem. 285(44):33816-33825(2010) Drury, G.L., et al. J. Biol. Chem. 285(41):31130-31138(2010) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Raspaglio, G., et al. Cancer Res. 70(14):5891-5900(2010) Ahn, J., et al. Retrovirology 7, 40 (2010)

Other Notes

Small volumes of anti-ELAVL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ELAVL1 purchase

MBS6121666 is an antibody targeting ELAVL1. Also known as ELAVL1 (ELAVL1, HUR, ELAV-like protein 1, Hu-antigen R) (PE). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ELAVL1. It may not necessarily be applicable to this product.

NCBI GI #
38201714
NCBI GeneID
1994
NCBI Accession #
NP_001410.2
UniProt Primary Accession #
Q15717
UniProt Secondary Accession #
Q53XN6; Q9BTT1
UniProt Related Accession #
Q15717
GenBank Nucleotide #
NM_001419.2
NCBI Official Full Name
ELAV-like protein 1
NCBI Official Synonym Full Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
NCBI Official Symbol
ELAVL1
NCBI Official Synonym Symbols
HUR; Hua; MelG; ELAV1
UniProt Protein Name
ELAV-like protein 1
UniProt Synonym Protein Names
Hu-antigen R; HuR
Protein Family
ELAV-like protein
UniProt Gene Name
ELAVL1
UniProt Synonym Gene Names
HUR; HuR
UniProt Entry Name
ELAV1_HUMAN
NCBI Protein Information
ELAV-like protein 1; Hu antigen R; hu-antigen R; embryonic lethal, abnormal vision, drosophila, homolog-like 1

UniProt Comments for ELAVL1

HuR: Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with ANP32A, EIF2C1 and EIF2C2. Ubiquitous. Belongs to the RRM elav family.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol; nucleus

Molecular Function: mRNA binding; protein binding; mRNA 3'-UTR binding; RNA binding; double-stranded RNA binding; nucleotide binding; AU-rich element binding; protein kinase binding

Biological Process: positive regulation of translation; multicellular organismal development; mRNA stabilization; gene expression
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ELAVL1 antibody

 Reference Product  PubMed Publications
 SET antibody  >1 publications with ELAVL1 and SET
 ANP32B antibody  >1 publications with ELAVL1 and ANP32B
 ANP32A antibody  >1 publications with ELAVL1 and ANP32A

Pathways associated with anti-ELAVL1 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of RNA Pathway antibodies  Metabolism Of RNA Pathway Diagram
 Metabolism Of MRNA Pathway antibodies  Metabolism Of MRNA Pathway Diagram
 Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway antibodies  Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway Diagram
 Stabilization Of MRNA By HuR Pathway antibodies  Stabilization Of MRNA By HuR Pathway Diagram

Diseases associated with anti-ELAVL1 antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >3 publications with ELAVL1 and Death
 Drug Toxicity Antibodies  >2 publications with ELAVL1 and Drug Toxicity
 Congenital Abnormalities Antibodies  >1 publications with ELAVL1 and Congenital Abnormalities
 Female Urogenital Diseases Antibodies  >1 publications with ELAVL1 and Female Urogenital Diseases
 Musculoskeletal Abnormalities Antibodies  >1 publications with ELAVL1 and Musculoskeletal Abnormalities
 Fetal Growth Retardation Antibodies  >1 publications with ELAVL1 and Fetal Growth Retardation
 Genetic Diseases, Inborn Antibodies  >1 publications with ELAVL1 and Genetic Diseases, Inborn
 Endometriosis Antibodies  >1 publications with ELAVL1 and Endometriosis
 Neoplasms Antibodies  >1 publications with ELAVL1 and Neoplasms
 Liver Diseases Antibodies  >1 publications with ELAVL1 and Liver Diseases

Organs/Tissues associated with anti-ELAVL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >3 publications with ELAVL1 and Eye
 Parathyroid Antibodies  >1 publications with ELAVL1 and Parathyroid
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000