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GFR Alpha2, in (GFRA2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS612193

Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) (1), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel… More details

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Product Overview

Online Datasheet in PDF
Product Name
GFR alpha2, IN (Gfra2), Polyclonal Antibody
Full Product Name
GFR alpha2, IN (Glycosylphosphadidylinositol linked Protein, GDNFRb, Ret ligand 2, RETL2)
Product Gene Name
Product Synonym Names
Anti -GFR alpha2, IN (Glycosylphosphadidylinositol linked Protein, GDNFRb, Ret ligand 2, RETL2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Purified
Purified IgG
Specificity
A 52kD band should be detected. The amino acid sequences of immunogenic peptide are identical to those of mouse and rat and recognizes GFRa-2 of human, mouse and rat origins.
Preparation and Storage
-20 degree C
Molecular Weight
51,727 Da
Chromosome Location
Chromosome: 14; NC_000080.5 (71289937..71379645). Location: 14; 14 D3-E1
3D Structure
ModBase 3D Structure for Q3UUD8
Immunogen
Peptide corresponding to amino acids 377 to 391 of human GFRa-2.
Applications Tested/Suitable for anti-Gfra2 antibody
Western Blot (WB)

Testing Data of anti-Gfra2 antibody

Rabbit Anti-GFRA2 Polyclonal Antibody – Cat# MBS612193

Testing Data of anti-Gfra2 antibody

Rabbit Anti-GFRA2 Polyclonal Antibody, Testing Data – Cat# MBS612193

Testing Data of anti-Gfra2 antibody

Rabbit Anti-GFRA2 Polyclonal Antibody, Testing Data – Cat# MBS612193

Other Notes

Small volumes of anti-Gfra2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Gfra2 purchase

MBS612193 is an antibody targeting Gfra2. Also known as GFR alpha2, IN (Glycosylphosphadidylinositol linked Protein, GDNFRb, Ret ligand 2, RETL2). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Gfra2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
GDNF family receptor alpha-2
NCBI Official Synonym Full Names
glial cell line derived neurotrophic factor family receptor alpha 2
NCBI Official Symbol
Gfra2
NCBI Official Synonym Symbols
Gfra2
UniProt Protein Name
Glial cell line derived neurotrophic factor family receptor alpha 2
Protein Family
UniProt Gene Name
Gfra2
UniProt Entry Name
Q3UUD8_MOUSE
NCBI Protein Information
GDNF family receptor alpha-2; GDNFR-beta; NTNR-alpha; GFR alpha 2; GFR alpha-2; GFR-alpha-2; NRTNR-alpha; GDNFR-alpha-2; GDNF receptor beta; GDNF receptor alpha-2; neurturin receptor alpha; TGF-beta-related neurotrophic factor receptor 2

NCBI Summary for Gfra2

The protein encoded by this gene is part of the receptor complex that transduces glial cell-derived neurotrophic factor and neurturin signals by mediating autophosphorylation and activation of the RET receptor. Mice lacking this protein are viable and fertile but display growth retardation attributed to impaired salivary and pancreatic secretion and innervation deficits in the intestinal tract. In addition, knockout mice display neural defects including a failure to initiate outgrowth of dorsal ganglion root neurons, demonstrating a requirement in neuronal differentiation of these cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
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UniProt Comments for Gfra2

GFRA2: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor

Cellular Component: membrane; plasma membrane

Molecular Function: receptor activity; glial cell line-derived neurotrophic factor receptor activity

Biological Process: nervous system development; cytokine and chemokine mediated signaling pathway; negative regulation of protein amino acid autophosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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