• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Tyrosinase (TYR) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6122488

MBS6122488 is an antibody targeting TYR. Also known as Tyrosinase (TYR) (PE). Reactive in Human. Host: Mouse. More details

$1105 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tyrosinase, Monoclonal Antibody
Full Product Name
Tyrosinase (TYR) (PE)
Product Gene Name
anti-TYR antibody
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
T311
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein G Affinity Chromatography
Specificity
Recognizes human tyrosinase, 70-80kD. Does not cross-react with MAGE-1 and tyrosinase-related protein-1, TRP-1/gp75. Staining of melanomas showed tyrosinase in melanotic as well as amelanotic variants.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
42,914 Da
OMIM
103470
3D Structure
ModBase 3D Structure for P14679
Immunogen
Recombinant protein corresponding to tyrosinase.
Conjugate
PE
Positive Control
SK-MEL-13, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells or Melanoma.
Special Handling
Light sensitive

Product Categories/Family for anti-TYR antibody

Antibodies; Disease Markers
Applications Tested/Suitable for anti-TYR antibody
Flow Cytometry (FC/FACS), FLISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-TYR antibody
FC/FACS: 0.5-1ug/10e6 cells
IP: 1-2ug/500ug protein lysate
IF: 1-2ug/ml
WB: 0.5-1ug/ml
Applications are based on unconjugated antibody.

Immunohistochemistry (IHC) of anti-TYR antibody

Formalin-fixed, paraffin-embedded human melanoma (10X) stained with Tyrosinase antibody (1:200), peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining.
Mouse Anti-TYR Monoclonal Antibody – Cat# MBS6122488

Immunohistochemistry (IHC) of anti-TYR antibody

Formalin-fixed, paraffin-embedded human melanoma (20X) stained with Tyrosinase antibody (1:200), peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining.
Mouse Anti-TYR Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6122488

Product References and Citations for anti-TYR antibody

1. Chen Y-T, et. al. Proc. Natl. Acad. Sci. USA, 1995, 92:8125-8129.

Other Notes

Small volumes of anti-TYR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TYR. It may not necessarily be applicable to this product.

NCBI GI #
4507753
NCBI GeneID
7299
NCBI Accession #
NP_000363
UniProt Primary Accession #
P14679
UniProt Secondary Accession #
Q15675; Q15676; Q15680; Q8TAK4; Q9BYY0; Q9BZX1
UniProt Related Accession #
P14679
GenBank Nucleotide #
NM_000372
NCBI Official Full Name
tyrosinase
NCBI Official Synonym Full Names
tyrosinase
NCBI Official Symbol
TYR
NCBI Official Synonym Symbols
ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
UniProt Protein Name
Tyrosinase
UniProt Synonym Protein Names
LB24-AB; Monophenol monooxygenase; SK29-AB; Tumor rejection antigen AB
Protein Family
Tyrosinase
UniProt Gene Name
TYR
UniProt Entry Name
TYRO_HUMAN
NCBI Protein Information
tyrosinase; LB24-AB; SK29-AB; monophenol monooxygenase; oculocutaneous albinism IA; tumor rejection antigen AB

UniProt Comments for TYR

TYR: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. Increased expression after UVB irradiation. Belongs to the tyrosinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; EC 1.14.18.1; Cofactor and Vitamin Metabolism - riboflavin; Amino Acid Metabolism - tyrosine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q14.3

Cellular Component: perinuclear region of cytoplasm; lysosome; melanosome membrane; cytoplasm; melanosome; integral to membrane; Golgi-associated vesicle

Molecular Function: protein binding; protein homodimerization activity; copper ion binding; protein heterodimerization activity; monophenol monooxygenase activity

Biological Process: cell proliferation; visual perception; thymus development; melanin biosynthetic process from tyrosine; eye pigment biosynthetic process

Disease: Albinism, Ocular, With Sensorineural Deafness; Albinism, Oculocutaneous, Type Ib; Albinism, Oculocutaneous, Type Ia; Skin/hair/eye Pigmentation, Variation In, 3
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TYR antibody

 Reference Product  PubMed Publications
 TYRP1 antibody  >98 publications with TYR and TYRP1

Pathways associated with anti-TYR antibody

 Products by Pathway  Pathway Diagram
 (S)-reticuline Biosynthesis Pathway antibodies  (S)-reticuline Biosynthesis Pathway Diagram
 (S)-reticuline Biosynthesis II Pathway antibodies  (S)-reticuline Biosynthesis II Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Dopamine Metabolism Pathway antibodies  Dopamine Metabolism Pathway Diagram
 L-dopachrome Biosynthesis Pathway antibodies  L-dopachrome Biosynthesis Pathway Diagram
 L-dopachrome Biosynthesis Pathway antibodies  L-dopachrome Biosynthesis Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram

Diseases associated with anti-TYR antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1870 publications with TYR and Neoplasms
 Nervous System Diseases Antibodies  >740 publications with TYR and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >389 publications with TYR and Cardiovascular Diseases
 Pain Antibodies  >378 publications with TYR and Pain
 Inflammation Antibodies  >331 publications with TYR and Inflammation
 Melanoma Antibodies  >312 publications with TYR and Melanoma
 Neoplasms, Experimental Antibodies  >264 publications with TYR and Neoplasms, Experimental
 Liver Diseases Antibodies  >200 publications with TYR and Liver Diseases
 Hypertension Antibodies  >190 publications with TYR and Hypertension
 Necrosis Antibodies  >185 publications with TYR and Necrosis

Organs/Tissues associated with anti-TYR antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >460 publications with TYR and Skin
 Eye Antibodies  >255 publications with TYR and Eye
 Thyroid Antibodies  >170 publications with TYR and Thyroid
 Connective Tissue Antibodies  >128 publications with TYR and Connective Tissue
 Mammary Gland Antibodies  >40 publications with TYR and Mammary Gland
 Ear Antibodies  >28 publications with TYR and Ear
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000