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MAP126 Protein (SPAG5) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS612554

A novel gene product, hMAP126, interacts with p29 in the yeast two-hybrid assay. The subcellular distribution of hMAP126 was localized to the mitotic spindle and is phosphorylated by p34(cdc2) kinase. Human MAP126 is likely involved in the functional and… More details

$830 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
MAP126 Protein (Spag5), Polyclonal Antibody
Full Product Name
MAP126 Protein (Mitotic Spindle Associated Protein p126, Astrin, Deepest, hMAP126, Mitotic Spindle Associated Protein, Mitotic Spindle Coiled Coil Related Protein, Sperm Associated Antigen 5, SPAG5, Sperm Tail Protein Spag5)
Product Gene Name
anti-Spag5 antibody
Product Synonym Names
Anti -MAP126 Protein (Mitotic Spindle Associated Protein p126, Astrin, Deepest, hMAP126, Mitotic Spindle Associated Protein, Mitotic Spindle Coiled Coil Related Protein, Sperm Associated Antigen 5, SPAG5, Sperm Tail Protein Spag5)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Purity/Purification
As reported
Specificity
Reacts with the human MAP126 protein.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
129,993 Da
Chromosome Location
chromosome: 11; Location: 11 B5; 11 44.95 cM
3D Structure
ModBase 3D Structure for Q7TME2

Product Categories/Family for anti-Spag5 antibody

Antibodies; Abs to Apoptosis
Applications Tested/Suitable for anti-Spag5 antibody
Western Blot (WB)
Application Notes for anti-Spag5 antibody
Suitable for use in Western Blot.

Other Notes

Small volumes of anti-Spag5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Spag5 purchase

MBS612554 is an antibody targeting Spag5. Also known as MAP126 Protein (Mitotic Spindle Associated Protein p126, Astrin, Deepest, hMAP126, Mitotic Spindle Associated Protein, Mitotic Spindle Coiled Coil Related Protein, Sperm Associated Antigen 5, SPAG5, Sperm Tail Protein Spag5). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Spag5. It may not necessarily be applicable to this product.

NCBI GI #
27462364
NCBI GeneID
54141
UniProt Primary Accession #
Q7TME2
UniProt Secondary Accession #
Q8CH61; B1AQC8
UniProt Related Accession #
Q62200; Q7TME2
NCBI Official Full Name
MAP126
NCBI Official Synonym Full Names
sperm associated antigen 5
NCBI Official Symbol
Spag5
NCBI Official Synonym Symbols
S17; MAP126; Deepest; Mastrin; AI874642; D11Bhm180e; Spag5
UniProt Protein Name
Sperm-associated antigen 5
UniProt Synonym Protein Names
Mastrin; Mitotic spindle-associated protein p126
Protein Family
Sperm-associated antigen
UniProt Gene Name
Spag5
UniProt Entry Name
SPAG5_MOUSE
NCBI Protein Information
sperm-associated antigen 5; astrin; OTTMUSP00000000156; microtubule-associated protein; mitotic spindle-associated protein p126

UniProt Comments for Spag5

SPAG5: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.

Protein type: Cell cycle regulation

Cellular Component: nucleoplasm; kinetochore; microtubule; cytoskeleton; spindle microtubule; cell; cytoplasm; spindle; chromosome; nucleus; chromosome, pericentric region

Molecular Function: microtubule binding

Biological Process: mitosis; regulation of attachment of spindle microtubules to kinetochore; mitotic sister chromatid segregation; cell division; establishment of spindle orientation; cell cycle; spindle organization and biogenesis; chromosome segregation
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Research Articles on Spag5

1. Loss-of-function of Astrin by RNAi and overexpression of the coiled-coil domain results in spindle disorganization, chromosome misalignment and meiosis progression arrest.
2. cloning and genomic structure of mastrin; mastrin protein was demonstrated to localize to mitotic spindles during mitosis[masatrin]
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Spag5 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with Spag5 and Neoplasms
 Gonadal Disorders Antibodies  >3 publications with Spag5 and Gonadal Disorders
 Neoplasm Metastasis Antibodies  >2 publications with Spag5 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >1 publications with Spag5 and Breast Neoplasms
 Lung Diseases Antibodies  >1 publications with Spag5 and Lung Diseases
 Adenocarcinoma Antibodies  >1 publications with Spag5 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >1 publications with Spag5 and Carcinoma, Squamous Cell
 Carcinoma Antibodies  >1 publications with Spag5 and Carcinoma
 Lung Neoplasms Antibodies  >1 publications with Spag5 and Lung Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with Spag5 and Congenital Abnormalities

Organs/Tissues associated with anti-Spag5 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >9 publications with Spag5 and Testis
 Blood Antibodies  >2 publications with Spag5 and Blood
 Brain Antibodies  >2 publications with Spag5 and Brain
 Pancreas Antibodies  >1 publications with Spag5 and Pancreas
 Lung Antibodies  >1 publications with Spag5 and Lung
 Heart Antibodies  >1 publications with Spag5 and Heart
 Lymph Node Antibodies  >1 publications with Spag5 and Lymph Node
 Eye Antibodies  >1 publications with Spag5 and Eye
 Embryonic Tissue Antibodies  >1 publications with Spag5 and Embryonic Tissue
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