CNG3 Antibody – Rabbit Polyclonal

The cyclic nucleotides cAMP and cGMP are implicated in signal transduction events such as the visual transduction, relaxation of smooth muscles, intestinal secretion of water and salt, reabsorption of Na+ and water in the distal tubule of the nephrons. cAMP/cGMP activate Ca2+ -permeable ion channels called cyclic nucleotide-gated channels (CNG or CNC). Activation of CNG leads to depolarization of the membrane voltage and to a concomitant increase of the cytosolic Ca2+. CNG consists of two distinct subunits, designated a and b subunits. Several CNG a-subunits (CNG alpha 1-3) & beta subunits (subunit 2 or CNGb1-2 or CNG4-5) and numerous isoforms. a-subunit can form functional channel by themselves, whereas, b-subunits modulate the channel property of a-subunits. CNG display intracellular N and C-termini, 6 transmembrane domains or segments (S1-S6). The region between S5 and S6 contains the ion-conducting pore (P). The cyclic nucleotide-binding region is found at the c-terminus. Native functional CNG may exists as heteromultimer containing some combination of a, and b subunits.

• (1). Misaka T et al (19970 J Biol. Chem. 272, 22623, Biel M et al (1999) PNAS 96, 7553, Wissinger B et al (1997) Eur. J. Neurosci. 9, 2512; Biel M et al (1994) PNAS 91, 3505; Weyand I et al (1994) Nature 368, 859

Small volumes of anti-CNG3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS612697 is an antibody targeting CNG3. Also known as Anti - CNG3 (Cyclic Nucleotide-Gated Channels 3). Reactive in Rat. Host: Rabbit
Source: Rat.