SAPK2 Antibody – Rabbit Polyclonal

p38 (HOG1), also known as SAPK-2, reactivating kinase or cytokine-suppressive binding protein, is a mouse 38 kD serine threonine kinase that belongs to the mitogen-activated protein kinase family (1). p38 is identified as one of the major tyrosine-phosphorylated proteins in mouse monocyte cell lines upon lipopolysachharide (LPS) treatment (2). Human homolog of p38 binds to cytokines suppressive anti-inflammatory drugs (CSAIDs), an anti-inflammatory drug that inhibits IL-1 and TNF-a synthesis (1). HOG1, the yeast homolog of p38, is stimulated by osmotic shock (3). p38 is activated by MAPK kinase MKK3 and Sek1/MKK4, the latter kinase is also involved in the activation of the stress-activated protein kinase pathway (4). In LPS-treated monocytic cells, the activity of a transcription activators called myocyte-enhancer factor 2 (MEF2) is increased through p38-catalysed phosphorylation, which results in increased c-jun gene transcription (5). p38 also activates MAPKAP kinase 2 in IL-1-stimulated cells (6).

Small volumes of anti-SAPK2, p38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS612762 is an antibody targeting SAPK2, p38. Also known as SAPK2, p38 (Stress-activated Protein Kinase 2, HOG1). Reactive in Bovine, Canine, Chicken, Guinea Pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep. Host: Rabbit.