Pyk2a Antibody – Rabbit Polyclonal

Protein tyrosine kinase Pyk2, also called CAKbeta, RAFTK and CADTK, is a nonreceptor tyrosine kinase structurally related to focal adhesion kinase (FAK) (1-4). Pyk2 is predominantly expressed in the cells derived from hematopoietic lineages and in the central nervous system. Pyk2 is one of the signaling mediators for the G-protein-coupled receptors and MAP kinase signaling pathway. It plays an important role in cell motility such as spreading and migration (5-7). Pyk2 is tyrosine phosphorylated and activated upon ligation of TCR (8,9). Phosphorylated tyrosine 402 of Pyk2 is required for the phosphorylation of other tyrosines on Pyk2 and provides a binding site for Fyn SH2 in the Tcell activation (10).

Small volumes of anti-Pyk2a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS612786 is an antibody targeting Pyk2a. Also known as Pyk2a, phosphorylated (Tyr402) (CAKbeta, cdk-activating Protein Kinase beta). Reactive in Human. Host: Rabbit.