Cleavage Site, P85 Asp214/Gly215 (PARP) Antibody – Rabbit Polyclonal

PARP plays a role in DNA repair as well as in other cellular processes, including DNA replication, cell proliferation and differentiation. During apoptosis, ICE family members, such as caspase-3 and -7, cleave PARP to yield an 85kD and a 25kD fragment. PARP cleavage is considered to be one of the classical characteristics of apoptosis. The antibody has been negatively preadsorbed using a peptide spanning the cleavage site to remove antibody that is reactive with full length PARP. The final product is generated by affinity chromatography using a peptide corresponding to the PARP cleavage site. Poly (ADP-Ribose) Polymerase (PARP) is a 116kD nuclear protein which is strongly activated by DNA strand breaks.

Small volumes of anti-PARP Cleavage Site, p85 Asp214/Gly215 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS612865 is an antibody targeting PARP Cleavage Site, p85 Asp214/Gly215. Also known as PARP Cleavage Site, p85 Asp214/Gly215 (Poly ADP-Ribose Polymerase). Reactive in Bovine, Human, Mouse, Rat. Host: Rabbit.