• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Spectrin, Alpha, Cleavage Site (SPTAN1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS612905

Spectrin is a universally expressed membrane-associated cytoskeletal protein consisting of alpha-and beta-subunits. This protein is important for maintaining normal membrane structure and supporting cell surface protein function. Alpha-spectrin is one of the… More details

$830 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Spectrin, alpha, Cleavage Site (SPTAN1), Polyclonal Antibody
Full Product Name
Spectrin, alpha, Cleavage Site (Asp1185) (Spectrin Non-erythroid alpha Chain, Alpha Fodrin, Alpha II Spectrin, FLJ44613, Spectrin alpha Non-erythrocytic 1, SPTAN1, SPTA2)
Product Gene Name
anti-SPTAN1 antibody
Product Synonym Names
Anti -Spectrin, alpha, Cleavage Site (Asp1185) (Spectrin Non-erythroid alpha Chain, Alpha Fodrin, Alpha II Spectrin, FLJ44613, Spectrin alpha Non-erythrocytic 1, SPTAN1, SPTA2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
Purity/Purification
Affinity Purified
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes endogenous levels of the large fragment of human Spectrin, alpha resulting from cleavage at aspartic acid 1185. Does not recognize full length Spectrin, alpha.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Molecular Weight
284,539 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (131314837..131395944). Location: 9q34.11
OMIM
182810
3D Structure
ModBase 3D Structure for Q13813
Immunogen
Synthetic peptide corresponding to amino-terminal residues surronding Asp1185 from human Spectrin, alpha conjugated to KLH.

Product Categories/Family for anti-SPTAN1 antibody

Antibodies; Abs to Spectrin
Applications Tested/Suitable for anti-SPTAN1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SPTAN1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000

Western Blot (WB) of anti-SPTAN1 antibody

Western Blot analysis of extracts from HeLa cells, untreated or staurosporine-treated, using MBS612905 (left) and S5381-01 (right).
Rabbit Anti-SPTAN1 Polyclonal Antibody – Cat# MBS612905

Immunocytochemistry (ICC) of anti-SPTAN1 antibody

Immunocytochemical staining of HeLa cells, untreated (A, C) or staurosporine-treated (B, D) , using MBS612905 Antibody (A, B) or S5381-01 (C, D).
Rabbit Anti-SPTAN1 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS612905

Other Notes

Small volumes of anti-SPTAN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPTAN1 purchase

MBS612905 is an antibody targeting SPTAN1. Also known as Spectrin, alpha, Cleavage Site (Asp1185) (Spectrin Non-erythroid alpha Chain, Alpha Fodrin, Alpha II Spectrin, FLJ44613, Spectrin alpha Non-erythrocytic 1, SPTAN1, SPTA2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SPTAN1. It may not necessarily be applicable to this product.

NCBI GI #
154759259
NCBI GeneID
6709
NCBI Accession #
NP_003118.2
UniProt Primary Accession #
Q13813
UniProt Secondary Accession #
Q13186; Q15324; Q16606; Q59EF1; Q5VXV5; Q5VXV6; Q7Z6M5; Q9P0V0
UniProt Related Accession #
Q13813
GenBank Nucleotide #
NM_003127.3
NCBI Official Full Name
spectrin alpha chain, non-erythrocytic 1 isoform 2
NCBI Official Synonym Full Names
spectrin, alpha, non-erythrocytic 1
NCBI Official Symbol
SPTAN1
NCBI Official Synonym Symbols
NEAS; EIEE5; SPTA2
UniProt Protein Name
Spectrin alpha chain, non-erythrocytic 1
UniProt Synonym Protein Names
Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit
Protein Family
Spectrin
UniProt Gene Name
SPTAN1
UniProt Synonym Gene Names
NEAS; SPTA2
UniProt Entry Name
SPTN1_HUMAN
NCBI Protein Information
spectrin alpha chain, non-erythrocytic 1; alpha-fodrin; alpha-II spectrin; fodrin alpha chain; spectrin, non-erythroid alpha chain; spectrin, non-erythroid alpha subunit

NCBI Summary for SPTAN1

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Show more

UniProt Comments for SPTAN1

SPTAN1: a cytoskeletal protein which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Capable to forming dimers which can further associate to tetramers.

Protein type: Cytoskeletal; Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: spectrin; microtubule cytoskeleton; intracellular membrane-bound organelle; membrane; fascia adherens; Z disc; cytosol; vesicle; lateral plasma membrane

Molecular Function: calmodulin binding; protein binding; spectrin binding; structural constituent of cytoskeleton; protein heterodimerization activity; calcium ion binding; actin binding

Biological Process: axon guidance; actin filament capping; apoptosis; cell structure disassembly during apoptosis

Disease: Epileptic Encephalopathy, Early Infantile, 5
Show more

Research Articles on SPTAN1

1. hypomyelination of the cerebral white matter was revealed at the age of 1 year, and a de novo heterozygous mutation in the SPTAN1 gene was confirmed

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SPTAN1 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram

Diseases associated with anti-SPTAN1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with SPTAN1 and Nervous System Diseases
 Brain Diseases Antibodies  >9 publications with SPTAN1 and Brain Diseases
 Neoplasms Antibodies  >5 publications with SPTAN1 and Neoplasms
 Atrophy Antibodies  >3 publications with SPTAN1 and Atrophy
 Movement Disorders Antibodies  >2 publications with SPTAN1 and Movement Disorders
 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 5 Antibodies  >2 publications with SPTAN1 and EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 5
 Precancerous Conditions Antibodies  >1 publications with SPTAN1 and Precancerous Conditions

Organs/Tissues associated with anti-SPTAN1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with SPTAN1 and Brain
 Vascular Antibodies  >3 publications with SPTAN1 and Vascular
 Nerve Antibodies  >3 publications with SPTAN1 and Nerve
 Blood Antibodies  >3 publications with SPTAN1 and Blood
 Bladder Antibodies  >1 publications with SPTAN1 and Bladder
 Stomach Antibodies  >1 publications with SPTAN1 and Stomach
 Muscle Antibodies  >1 publications with SPTAN1 and Muscle
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000