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Peroxiredoxin 6 (PRDX6) Antibody – Sheep Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS612933

MBS612933 is an antibody targeting PRDX6. Also known as Peroxiredoxin 6 (PRDX-6, Prdx6-rs3, AA690119, 1-Cys Peroxiredoxin, 1-Cys-PRX, 1-CysPrx, 9430088D19Rik, Acidic Calcium-independent Phospholipase A2, aiPLA2, Antioxidant Protein 2, AOP2, AOP2-rs3, Brp-12,… More details

$940 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Peroxiredoxin 6 (PRDX6), Polyclonal Antibody
Full Product Name
Peroxiredoxin 6 (PRDX-6, Prdx6-rs3, AA690119, 1-Cys Peroxiredoxin, 1-Cys-PRX, 1-CysPrx, 9430088D19Rik, Acidic Calcium-independent Phospholipase A2, aiPLA2, Antioxidant Protein 2, AOP2, AOP2-rs3, Brp-12, Ciliary Body Glutathione Peroxidase, CP-3, EC 1.11.1
Product Gene Name
anti-PRDX6 antibody
Product Synonym Names
Anti -Peroxiredoxin 6 (PRDX-6, Prdx6-rs3, AA690119, 1-Cys Peroxiredoxin, 1-Cys-PRX, 1-CysPrx, 9430088D19Rik, Acidic Calcium-independent Phospholipase A2, aiPLA2, Antioxidant Protein 2, AOP2, AOP2-rs3, Brp-12, Ciliary Body Glutathione Peroxidase, CP-3, EC 1.11.1
Clonality
Polyclonal
Host
Sheep
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material.
Purity/Purification
Serum
Serum
Specificity
This antibody has been shown to be specific for Peroxiredoxin-6 protein. Species Crossreactivity: Rat, human and mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
25,021 Da
Chromosome Location
Chromosome: 1; NC_012591.1 (77521466..77528902, complement)
3D Structure
ModBase 3D Structure for Q5R7E0
Immunogen
Rat recombinant Peroxiredoxin-6.
Cellular Localization
Cytoplasm. Lysosome. Note=Also found in lung secretory organelles. The active site is the redox-active Cys-47 oxidized to Cys-SOH. Cys-SOH may rapidly react with a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin. Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress. Belongs to the ahpC/TSA family. Rehydrin subfamily.

Product Categories/Family for anti-PRDX6 antibody

Antibodies; Abs to Enzymes; Peroxiredoxin
Applications Tested/Suitable for anti-PRDX6 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PRDX6 antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.

Other Notes

Small volumes of anti-PRDX6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDX6. It may not necessarily be applicable to this product.

NCBI GI #
197099987
NCBI GeneID
100173342
NCBI Accession #
NP_001126361.1
UniProt Primary Accession #
Q5R7E0
UniProt Related Accession #
Q5R7E0
GenBank Nucleotide #
NM_001132889.1
NCBI Official Full Name
peroxiredoxin-6
NCBI Official Symbol
PRDX6
NCBI Official Synonym Symbols
DKFZp469L171
UniProt Protein Name
Peroxiredoxin-6
Protein Family
Peroxiredoxin
UniProt Gene Name
PRDX6
UniProt Entry Name
PRDX6_PONAB
NCBI Protein Information
peroxiredoxin-6

UniProt Comments for PRDX6

Function: Involved in redox regulation of the cell. Can reduce H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury

Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

Subunit structure: Homotetramer. May interact with HTR2A. Interacts with APEX1 and STH

Subcellular location: Cytoplasm

By similarity. Lysosome

By similarity. Cytoplasmic vesicle

By similarity. Note: Also found in lung secretory organelles

Miscellaneous: The active site is the redox-active Cys-47 oxidized to Cys-SOH. Cys-SOH may rapidly react with a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin

By similarity.Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO3H) upon oxidative stress

Sequence similarities: Belongs to the ahpC/TSA family. Rehydrin subfamily.Contains 1 thioredoxin domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PRDX6 antibody

 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram

Diseases associated with anti-PRDX6 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13 publications with PRDX6 and Neoplasms
 Death Antibodies  >11 publications with PRDX6 and Death
 Lung Diseases Antibodies  >11 publications with PRDX6 and Lung Diseases
 Drug Toxicity Antibodies  >10 publications with PRDX6 and Drug Toxicity
 Lung Injury Antibodies  >10 publications with PRDX6 and Lung Injury
 Inflammation Antibodies  >9 publications with PRDX6 and Inflammation
 Necrosis Antibodies  >7 publications with PRDX6 and Necrosis
 Neurodegenerative Diseases Antibodies  >6 publications with PRDX6 and Neurodegenerative Diseases
 Atherosclerosis Antibodies  >6 publications with PRDX6 and Atherosclerosis
 Acute Lung Injury Antibodies  >5 publications with PRDX6 and Acute Lung Injury
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