Neurite Outgrowth Inhibitor Protein B Antibody – Rabbit Polyclonal

Many tissues such as muscle, skin, liver, and peripheral nerve, have remarkable ability to repair and regrowafter injury. The CNS (brain and spinal cord) is limited in its ability to repair or regrowth causing permanent brain damage or paralyses. An inhibitory myelin protein, Nogo (Neurite outgrowth), has been cloned and characterized. It may help block the regeneration of the CNS. Nogo is the 4th member of reticulon (Rtn) family. There are three alternative isoforms of Nogo. Nogo-A is full length human protein consisting of 1192aa, Mr ~135kD (rat 1163aa). Nogo-B is an intermediate form consistiong of 373aa, ~37kD. Nogo-B lacks aa186-1004 within the extracellular domain. Nogo-C is shorter consisting of 199aa, ~25kD. It lacks aa186-1004 and has a smaller, alternative N-terminal domain. It is similar to rat vp20 and foocen-s. Nogo-A has a putative extracellular domain of 1024aa, 2-3 TM domains, and a short C-terminus of 43aa. Nogo-A is localized to the CNS-myelin. It is highly expressed in oligodendorcytes, but not by Schwann cells. Nogo-B and Nogo-C have been found in several non-neuronal tissues (skeletal muscle, kidney, skin, lung, and spleen).

Small volumes of anti-Neurite Outgrowth Inhibitor Protein B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS613150 is an antibody targeting Neurite Outgrowth Inhibitor Protein B. Also known as Neurite Outgrowth Inhibitor Protein B (NogoB). Reactive in Rat. Host: Rabbit.