Rabbit Anti-OATP3 Polyclonal Antibody – Cat# MBS613180

OATP3 Antibody – Rabbit Polyclonal

Name: OATP3 Antibody; Polyclonal; Rabbit; Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS613180
Price: 965 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS613180

Mammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs, and other organic anions from the blood by a process called "renal secretion". Besides kidney, anionic substrates are also… More details

$965 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

OATP3 (Organic Anion Transporting Polypeptide 3), Polyclonal Antibody

Full Product Name

Rabbit anti-Rat OATP3 (Organic Anion Transporting Polypeptide 3)

Product Gene Name

anti-OATP3 antibody

Product Synonym Names

Anti -OATP3 (Organic Anion Transporting Polypeptide 3)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Rat

Form/Format

Supplied as a liquid in PBS. pH 7.2, 0.1% BSA

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Concentration

~1 mg/ml (after reconstitution) (lot specific)

Specificity

Recognizes rat Oatp3. No significant sequence homology with other Oatp2, Oatp3 or human OATP or LST-1.

Preparation and Storage

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Chromosome Location

Chromosome: 4; NC_005103.2 (179790209..179851288, complement). Location: 4q44

3D Structure

ModBase 3D Structure for O88397

Immunogen

Synthetic peptide consisting of 12aa sequence within the mid-region of rat Oatp3 conjugated with KLH. Species Sequence Homology: mouse Oatp3: 75%.

Control Peptide

Catalog # (please inquire): OATP3, Rat, Control Peptide (Organic Anion Transporting Polypeptide 3)

Product Categories/Family for anti-OATP3 antibody

Antibodies; Abs to Ion Channel

Applications Tested/Suitable for anti-OATP3 antibody

Suitable for use in ELISA (EIA), Western Blot, though not tested, may potentially be used as an application. Other applications not tested.

Application Notes for anti-OATP3 antibody

Suitable for use in ELISA. Other potential application, though not tested is Western Blot. Other applications not tested.
Recommended Dilutions
ELISA: 0.5-1ug/ml Control peptide can be used to coat ELISA plates at 1ug/ml. Optimal dilutions to be determined by the researcher.

Product References and Citations for anti-OATP3 antibody

Naud, J.; J. Pharmacol. Exp. Ther. 320:978-985 (2007). 2. Abe, T., et al., J. Biol. Chem. 273: 22395-22401 (1998). 3. Noe, B., et al., PNAS 94: 10346-10350 (1997). 4. Abe, T., et al., J. Biol. Chem. 273: 22395-22401 (1998). 5. Kakyo, M., et al., FEBS Lett. 445: 343-346 (1999).

Other Notes

Small volumes of anti-OATP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OATP3 purchase

MBS613180 is an antibody targeting OATP3. Also known as Rabbit anti-Rat OATP3 (Organic Anion Transporting Polypeptide 3). Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OATP3. It may not necessarily be applicable to this product.

NCBI GI #

3420183

NCBI GeneID

80900

UniProt Primary Accession #

O88397

UniProt Secondary Accession #

Q9EQR8

UniProt Related Accession #

O88397

NCBI Official Full Name

organic anion transporter protein 3

NCBI Official Synonym Full Names

solute carrier organic anion transporter family, member 1a5

NCBI Official Symbol

Slco1a5

NCBI Official Synonym Symbols

Oatp3; OATP-3; Slc21a7; Slco1a2

UniProt Protein Name

Solute carrier organic anion transporter family member 1A5

UniProt Synonym Protein Names

Organic anion-transporting polypeptide 3; OATP-3; Sodium-independent organic anion transporter 3; Solute carrier family 21 member 7

UniProt Gene Name

Slco1a5

UniProt Synonym Gene Names

Oatp1a5; Oatp3; Slc21a7; Slco1a2

UniProt Entry Name

SO1A5_RAT

NCBI Protein Information

solute carrier organic anion transporter family member 1A5; solute carrier family 21 member 7; organic anion transporting polypeptide 3; organic anion-transporting polypeptide 3; sodium-independent organic anion transporter 3; solute carrier family 21 (fatty acid transporter) member 7; solute carrier organic anion transporter family, member 1A2

NCBI Summary for OATP3

facilitates renal uptake and excretion of the uremic toxin indoxyl sulfate; may facilitate intestinal absorption of bile acids; transports thyroid hormones and taurocholate [RGD]

UniProt Comments for OATP3

Function: Mediates the Na+-independent transport of organic anions such as taurocholate and thyroid hormones.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Tissue specificity: Highly expressed in the kidney and moderately abundant in the retina.

Sequence similarities: Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]Contains 1 Kazal-like domain.

Research Articles on OATP3

1. consistently suggested that Oatp1a5 is contributing to the intestinal absorption

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-OATP3 antibody

Products by Pathway	Pathway Diagram
Bile Acid And Bile Salt Metabolism Pathway antibodies	Bile Acid And Bile Salt Metabolism Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Recycling Of Bile Acids And Salts Pathway antibodies	Recycling Of Bile Acids And Salts Pathway Diagram
SLC-mediated Transmembrane Transport Pathway antibodies	SLC-mediated Transmembrane Transport Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram
Transport Of Organic Anions Pathway antibodies	Transport Of Organic Anions Pathway Diagram
Transport Of Vitamins, Nucleosides, And Related Molecules Pathway antibodies	Transport Of Vitamins, Nucleosides, And Related Molecules Pathway Diagram

Diseases associated with anti-OATP3 antibody

Disease Name	Pubmed Publications
Liver Cirrhosis, Experimental Antibodies	>1 publications with OATP3 and Liver Cirrhosis, Experimental
Drug Toxicity Antibodies	>1 publications with OATP3 and Drug Toxicity
Fibrosis Antibodies	>1 publications with OATP3 and Fibrosis

Organs/Tissues associated with anti-OATP3 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>6 publications with OATP3 and Kidney