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Vasopressin Receptor, Arg, V1a (AVPR1A) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS613195

MBS613195 is an antibody targeting Avpr1a. Also known as Vasopressin Receptor, Arg, V1a (AVR-V1a). Reactive in Rat. Host: Rabbit. More details

$980 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Vasopressin Receptor, Arg, V1a (Avpr1a), Polyclonal Antibody
Full Product Name
Vasopressin Receptor, Arg, V1a (AVR-V1a)
Product Gene Name
anti-Avpr1a antibody
Product Synonym Names
Anti -Vasopressin Receptor, Arg, V1a (AVR-V1a)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.1% BSA, 0.1% sodium azide, 40% glycerol.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
The 18 aa rat peptide has 100% sequence homology with rat AVP1a receptors (394, 395 and 424 aa) and 55% with mouse (10/18 aa) AVR-V1a receptors. Sequence homology of the peptide with the human AVR-V1a was not significant. No significant similarity is seen with AVP V1b or V2 or V3 receptors.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
47,182 Da
Chromosome Location
Chromosome: 10; NC_000076.5 (121885555..121890509). Location: 10; 10 D3
3D Structure
ModBase 3D Structure for Q3U1H9
Immunogen
An 18 aa peptide sequence within the cytoplasmic domain between the TM5 and TM6, selected for antibody. The peptide was synthesized as Cysteine at the NH2-terminus and coupled to KLH

Product Categories/Family for anti-Avpr1a antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-Avpr1a antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Avpr1a antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 0.5-1ug/ml
Western Blot: 1-10ug/ml
Optimal dilutions to be determined by the researcher.

Other Notes

Small volumes of anti-Avpr1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Avpr1a. It may not necessarily be applicable to this product.

NCBI GI #
33149329
NCBI GeneID
54140
NCBI Accession #
NP_058543.2
UniProt Primary Accession #
Q3U1H9
UniProt Related Accession #
Q3U1H9; Q3UEE1; Q62463
GenBank Nucleotide #
NM_016847.2
NCBI Official Full Name
vasopressin V1a receptor
NCBI Official Synonym Full Names
arginine vasopressin receptor 1A
NCBI Official Symbol
Avpr1a
NCBI Official Synonym Symbols
V1a; AVPR; V1aR; Avpr1
UniProt Protein Name
Arginine vasopressin receptor 1A
Protein Family
Vasopressin V1a receptor
UniProt Gene Name
Avpr1a
UniProt Entry Name
Q3U1H9_MOUSE
NCBI Protein Information
vasopressin V1a receptor; AVPR V1a; OTTMUSP00000022915; antidiuretic hormone receptor 1a; V1a arginine vasopressin receptor; vascular/hepatic-type arginine vasopressin receptor

NCBI Summary for Avpr1a

This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues [provided by RefSeq]
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UniProt Comments for Avpr1a

AVPR1A: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Cellular Component: membrane; integral to plasma membrane; integral to membrane; plasma membrane; cytoplasmic vesicle; cytosol

Molecular Function: G-protein coupled receptor activity; signal transducer activity; peptide hormone binding; V1A vasopressin receptor binding; peptide binding; vasopressin receptor activity

Biological Process: grooming behavior; response to inorganic substance; maternal behavior; positive regulation of cellular pH reduction; calcium-mediated signaling; positive regulation of glutamate secretion; positive regulation of heart rate; positive regulation of systemic arterial blood pressure; social behavior; signal transduction; positive regulation of cell growth; cellular response to hormone stimulus; response to organic substance; negative regulation of female receptivity; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; negative regulation of transmission of nerve impulse; regulation of systemic arterial blood pressure by vasopressin; positive regulation of cell proliferation; positive regulation of vasoconstriction; sperm ejaculation; positive regulation of blood pressure; positive regulation of prostaglandin biosynthetic process; penile erection
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Research Articles on Avpr1a

1. Aldosterone requires vasopressin V1a receptors on intercalated cells to mediate acid-base homeostasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Avpr1a antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram

Diseases associated with anti-Avpr1a antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >268 publications with Avpr1a and Brain Diseases
 Central Nervous System Diseases Antibodies  >257 publications with Avpr1a and Central Nervous System Diseases
 Hemorrhage Antibodies  >132 publications with Avpr1a and Hemorrhage
 Liver Diseases Antibodies  >102 publications with Avpr1a and Liver Diseases
 Edema Antibodies  >94 publications with Avpr1a and Edema
 Liver Cirrhosis Antibodies  >92 publications with Avpr1a and Liver Cirrhosis
 Inflammation Antibodies  >83 publications with Avpr1a and Inflammation
 Neurologic Manifestations Antibodies  >81 publications with Avpr1a and Neurologic Manifestations
 Body Weight Changes Antibodies  >58 publications with Avpr1a and Body Weight Changes
 Drug Toxicity Antibodies  >55 publications with Avpr1a and Drug Toxicity

Organs/Tissues associated with anti-Avpr1a antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2365 publications with Avpr1a and Brain
 Kidney Antibodies  >1339 publications with Avpr1a and Kidney
 Muscle Antibodies  >604 publications with Avpr1a and Muscle
 Liver Antibodies  >510 publications with Avpr1a and Liver
 Bladder Antibodies  >92 publications with Avpr1a and Bladder
 Skin Antibodies  >50 publications with Avpr1a and Skin
 Embryonic Tissue Antibodies  >44 publications with Avpr1a and Embryonic Tissue
 Eye Antibodies  >33 publications with Avpr1a and Eye
 Spleen Antibodies  >19 publications with Avpr1a and Spleen
 Connective Tissue Antibodies  >17 publications with Avpr1a and Connective Tissue
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