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Brevican (BCAN) Antibody – Sheep Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS613677

Brevican (brain-enriched hyaluronan-binding protein) is a 160kD member of the aggrecan/versican proteoglycan family of matrix proteins. It is brain-derived and serves as a linker between HA and other matrix molecules such as tenascins and fibulins. Mature… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Brevican (BCAN), Polyclonal Antibody
Full Product Name
Brevican (BEHAB, Brain-Enriched Hyaluronan-Binding Protein)
Product Gene Name
anti-BCAN antibody
Product Synonym Names
Anti -Brevican (BEHAB, Brain-Enriched Hyaluronan-Binding Protein)
Clonality
Polyclonal
Isotype
IgG
Host
Sheep
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol.
Purity/Purification
Affinity Purified
Purified by human Brevican affinity chromatography.
Specificity
Recognizes human Brevican.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
99,118 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (156611740..156629320). Location: 1q31
OMIM
600347
3D Structure
ModBase 3D Structure for Q96GW7
Immunogen
NS0-derived recombinant human Brevican isoform 1 (aa23-911) Accession # Q96GW7, Lys504Glu substitution

Product Categories/Family for anti-BCAN antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-BCAN antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-BCAN antibody
Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 0.1-0.2ug/ml
ELISA: 0.5-1ug/ml

Immunocytochemistry (ICC) of anti-BCAN antibody

Immunocytochemistry- Brevican in Rat Cortical Stem Cells.
Sheep Anti-BCAN Polyclonal Antibody – Cat# MBS613677

Immunohistochemistry (IHC) of anti-BCAN antibody

Immunohistochemistry- Brevican in Human Brain.
Sheep Anti-BCAN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS613677

Other Notes

Small volumes of anti-BCAN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCAN purchase

MBS613677 is an antibody targeting BCAN. Also known as Brevican (BEHAB, Brain-Enriched Hyaluronan-Binding Protein). Reactive in Human. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for BCAN. It may not necessarily be applicable to this product.

NCBI GI #
20380804
NCBI GeneID
63827
UniProt Primary Accession #
Q96GW7
UniProt Secondary Accession #
Q5SZ10; Q5T3I5; Q8TBB9; Q9HBK1; Q9HBK4; D3DVC2
UniProt Related Accession #
Q59F90; Q5T3I7; Q5T3I8; Q8IWX2; Q96GW7; Q9NT67
NCBI Official Full Name
Brevican
NCBI Official Synonym Full Names
brevican
NCBI Official Symbol
BCAN
NCBI Official Synonym Symbols
BEHAB; CSPG7; MGC13038
UniProt Protein Name
Brevican core protein
UniProt Synonym Protein Names
Brain-enriched hyaluronan-binding protein; BEHAB; Chondroitin sulfate proteoglycan 7
Protein Family
Brevican core protein
UniProt Gene Name
BCAN
UniProt Synonym Gene Names
BEHAB; CSPG7
UniProt Entry Name
PGCB_HUMAN
NCBI Protein Information
brevican core protein; OTTHUMP00000032164; OTTHUMP00000032165; brevican proteoglycan; chondroitin sulfate proteoglycan 7; chondroitin sulfate proteoglycan BEHAB; brain-enriched hyaluronan-binding protein; chondroitin sulfate proteoglycan BEHAB/brevican

NCBI Summary for BCAN

This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
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UniProt Comments for BCAN

BCAN: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Belongs to the aggrecan/versican proteoglycan family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: proteinaceous extracellular matrix; lysosomal lumen; Golgi lumen; extracellular region

Molecular Function: extracellular matrix structural constituent; hyaluronic acid binding; carbohydrate binding

Biological Process: chondroitin sulfate metabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; central nervous system development; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; chondroitin sulfate catabolic process; hippocampus development; carbohydrate metabolic process; pathogenesis; cell adhesion; skeletal development; dermatan sulfate biosynthetic process
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Research Articles on BCAN

1. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BCAN antibody

 Reference Product  PubMed Publications
 ADAMTS4 antibody  >3 publications with BCAN and ADAMTS4
 TNR antibody  >1 publications with BCAN and TNR

Pathways associated with anti-BCAN antibody

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Dermatan Sulfate Biosynthesis Pathway antibodies  Dermatan Sulfate Biosynthesis Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway antibodies  Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram

Organs/Tissues associated with anti-BCAN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >58 publications with BCAN and Brain
 Lung Antibodies  >2 publications with BCAN and Lung
 Liver Antibodies  >1 publications with BCAN and Liver
 Skin Antibodies  >1 publications with BCAN and Skin
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