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GLP2R Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6136782

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. More details

$1155 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GLP2R, Monoclonal Antibody
Full Product Name
GLP2R (Glucagon-like Peptide 2 Receptor, GLP-2 Receptor, GLP-2-R, GLP-2R) APC
Product Gene Name
anti-GLP2R antibody
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
1F2
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human GLP2R.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
61kDa
OMIM
603659
3D Structure
ModBase 3D Structure for O95838
Immunogen
Partial recombinant corresponding to aa69-178 from GLP2R with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
LEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTL
Conjugate
APC

Product Categories/Family for anti-GLP2R antibody

Antibodies; Receptors
Applications Tested/Suitable for anti-GLP2R antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-GLP2R antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-GLP2R antibody

Western Blot detection against Immunogen using (37.84kD).
Mouse Anti-GLP2R Monoclonal Antibody – Cat# MBS6136782

Testing Data of anti-GLP2R antibody

Detection limit for recombinant GST tagged GLP2R is ~10ng/ml using as a capture antibody.
Mouse Anti-GLP2R Monoclonal Antibody, Testing Data – Cat# MBS6136782

Other Notes

Small volumes of anti-GLP2R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLP2R purchase

MBS6136782 is an antibody targeting GLP2R. Also known as GLP2R (Glucagon-like Peptide 2 Receptor, GLP-2 Receptor, GLP-2-R, GLP-2R) APC. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for GLP2R. It may not necessarily be applicable to this product.

NCBI GI #
4758438
NCBI GeneID
9340
NCBI Accession #
NP_004237
UniProt Primary Accession #
O95838
UniProt Related Accession #
O95838
GenBank Nucleotide #
NM_004246
NCBI Official Full Name
glucagon-like peptide 2 receptor
NCBI Official Synonym Full Names
glucagon like peptide 2 receptor
NCBI Official Symbol
GLP2R
UniProt Protein Name
Glucagon-like peptide 2 receptor
Protein Family
Glucagon-like peptide 2 receptor
UniProt Gene Name
GLP2R
UniProt Synonym Gene Names
GLP-2 receptor; GLP-2-R; GLP-2R
UniProt Entry Name
GLP2R_HUMAN
NCBI Protein Information
glucagon-like peptide 2 receptor

NCBI Summary for GLP2R

This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
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UniProt Comments for GLP2R

GLP2R: This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; glucagon receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; positive regulation of cell proliferation
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Research Articles on GLP2R

1. GLP2R expression was significantly increased in gastric chief cells in OB and OWD patients. PKCzeta expression was also significantly increased. This is the first evidence of increased GLP2R expression in chief cells of patients with severe obesity regardless of diabetes status.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GLP2R antibody

 Reference Product  PubMed Publications
 GCG antibody  >4 publications with GLP2R and GCG
 GCGR antibody  >2 publications with GLP2R and GCGR

Pathways associated with anti-GLP2R antibody

 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Glucagon-type Ligand Receptors Pathway antibodies  Glucagon-type Ligand Receptors Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Organs/Tissues associated with anti-GLP2R antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >10 publications with GLP2R and Intestine
 Brain Antibodies  >3 publications with GLP2R and Brain
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