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SERPIND1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS613808

MBS613808 is an antibody targeting SERPIND1. Also known as SERPIND1 (Serine/Cysteine Proteinase Inhibitor, Clade D, Member 1) (Biotin). Reactive in Human. Host: Goat. More details

$1090 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SERPIND1, Polyclonal Antibody
Full Product Name
SERPIND1 (Serine/Cysteine Proteinase Inhibitor, Clade D, Member 1) (Biotin)
Product Gene Name
anti-SERPIND1 antibody
Product Synonym Names
Anti -SERPIND1 (Serine/Cysteine Proteinase Inhibitor, Clade D, Member 1) (Biotin)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS containing 50ug of BSA per 1ug of antibody. Reconstitute with sterile TBS, pH 7.3 (20mM Trizma base, 150mM sodium chloride) containing 0.1% BSA, 40-50% glycerol. If 1ml of buffer is us
Purity/Purification
Affinity Purified
Purified by human Serpin D1 affinity chromatography and then biotinylated.
Specificity
Selected for use as a detection antibody in human Serpin D1 Western Blots.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile TBS with 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
57,071 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (21128383..21142008). Location: 22q11.2; 22q11.21
OMIM
142360
3D Structure
ModBase 3D Structure for P05546
Immunogen
Sf21-derived rhSerpin D1 (aa20-499)

Product Categories/Family for anti-SERPIND1 antibody

Antibodies; Abs to Protease Inhibitors
Applications Tested/Suitable for anti-SERPIND1 antibody
Western Blot (WB)
Application Notes for anti-SERPIND1 antibody
Western Blot: This antibody can be used at 0.1-0.2ug/ml with the appropriate secondary reagents to detect recombinant human Serpin D1. The detection limit for rhSerpin D1 is approximately 2 ng/lane under non-reducing and reducing conditions. In this format, this antibody shows approximately 40% cross-reactivity with rmSerpin D1., Optimal dilutions should be determined by each laboratory for each application.

Other Notes

Small volumes of anti-SERPIND1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPIND1. It may not necessarily be applicable to this product.

NCBI GI #
47678677
NCBI GeneID
3053
UniProt Primary Accession #
P05546
UniProt Secondary Accession #
Q6IBZ5; B2RAI1; D3DX34
UniProt Related Accession #
P05546; Q8IVC0
NCBI Official Full Name
SERPIND1
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
NCBI Official Symbol
SERPIND1
NCBI Official Synonym Symbols
HC2; LS2; HCF2; HCII; HLS2; D22S673
UniProt Protein Name
Heparin cofactor 2
UniProt Synonym Protein Names
Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; HLS2; Serpin D1
Protein Family
Heparin cofactor
UniProt Gene Name
SERPIND1
UniProt Synonym Gene Names
HCF2
UniProt Entry Name
HEP2_HUMAN
NCBI Protein Information
heparin cofactor 2; serpin D1; leuserpin 2; OTTHUMP00000198450; OTTHUMP00000198451; protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1

NCBI Summary for SERPIND1

The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq]
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UniProt Comments for SERPIND1

SERPIND1: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10). A hemostatic disorder characterized by a tendency to recurrent thrombosis. Belongs to the serpin family.

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; heparin binding; endopeptidase inhibitor activity

Biological Process: blood coagulation; chemotaxis

Disease: Heparin Cofactor Ii Deficiency
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Research Articles on SERPIND1

1. Plasma heparin cofactor II activity was independently and inversely associated with the development of cardiac remodeling, including cardiac concentric change, left atrial enlargement and left ventricular diastolic dysfunction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SERPIND1 antibody

 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram

Diseases associated with anti-SERPIND1 antibody

 Disease Name  Pubmed Publications
 Arteriosclerosis Antibodies  >2 publications with SERPIND1 and Arteriosclerosis
 Thrombosis Antibodies  >2 publications with SERPIND1 and Thrombosis
 Myocardial Infarction Antibodies  >1 publications with SERPIND1 and Myocardial Infarction
 Myocardial Ischemia Antibodies  >1 publications with SERPIND1 and Myocardial Ischemia
 Necrosis Antibodies  >1 publications with SERPIND1 and Necrosis
 Death Antibodies  >1 publications with SERPIND1 and Death
 HEPARIN COFACTOR II DEFICIENCY Antibodies  >1 publications with SERPIND1 and HEPARIN COFACTOR II DEFICIENCY

Organs/Tissues associated with anti-SERPIND1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with SERPIND1 and Liver
 Vascular Antibodies  >2 publications with SERPIND1 and Vascular
 Kidney Antibodies  >1 publications with SERPIND1 and Kidney
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