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Neuropeptide FF2 Receptor Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS613892

The central nervous system neuropeptide FF (NPFF), is believed to play a role in pain modulation and opiate tolerance as well as other physiological functions. Two G protein-coupled receptors, NPFF1 and NPFF2, were isolated from the human central nervous… More details

$875 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Neuropeptide FF2 Receptor (NPFFR2), Polyclonal Antibody
Full Product Name
Neuropeptide FF2 Receptor (NPFF2, G-protein Coupled Receptor 74, GPR74, G-protein Coupled Receptor HLWAR77, HLWAR77, Neuropeptide FF-2, NPFF2, Neuropeptide FF Receptor 2, NPFFR2, Neuropeptide G-protein Coupled Receptor, NPGPR)
Product Gene Name
anti-NPFFR2 antibody
Product Synonym Names
Anti -Neuropeptide FF2 Receptor (NPFF2, G-protein Coupled Receptor 74, GPR74, G-protein Coupled Receptor HLWAR77, HLWAR77, Neuropeptide FF-2, NPFF2, Neuropeptide FF Receptor 2, NPFFR2, Neuropeptide G-protein Coupled Receptor, NPGPR)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Purity/Purification
As reported
Specificity
Reacts with the N terminal sequence MNEKWDTNSSENWHPI and the C terminal sequence ELVMEELKETTNSSEI of the human NPFF2 protein.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
60,270 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (72897521..73013918). Location: 4q21
OMIM
607449
3D Structure
ModBase 3D Structure for Q9Y5X5

Product Categories/Family for anti-NPFFR2 antibody

Antibodies; Abs to G Protein Receptors
Applications Tested/Suitable for anti-NPFFR2 antibody
Western Blot (WB)
Application Notes for anti-NPFFR2 antibody
Suitable for use in Western Blot.

Other Notes

Small volumes of anti-NPFFR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NPFFR2 purchase

MBS613892 is an antibody targeting NPFFR2. Also known as Neuropeptide FF2 Receptor (NPFF2, G-protein Coupled Receptor 74, GPR74, G-protein Coupled Receptor HLWAR77, HLWAR77, Neuropeptide FF-2, NPFF2, Neuropeptide FF Receptor 2, NPFFR2, Neuropeptide G-protein Coupled Receptor, NPGPR). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NPFFR2. It may not necessarily be applicable to this product.

NCBI GI #
221316654
NCBI GeneID
10886
NCBI Accession #
NP_004876.2
UniProt Primary Accession #
Q9Y5X5
UniProt Secondary Accession #
Q96RV1; Q9NR49
UniProt Related Accession #
Q9Y5X5
GenBank Nucleotide #
NM_004885.2
NCBI Official Full Name
neuropeptide FF receptor 2 isoform 1
NCBI Official Synonym Full Names
neuropeptide FF receptor 2
NCBI Official Symbol
NPFFR2
NCBI Official Synonym Symbols
GPR74; NPFF2; NPGPR; HLWAR77
UniProt Protein Name
Neuropeptide FF receptor 2
UniProt Synonym Protein Names
G-protein coupled receptor 74; G-protein coupled receptor HLWAR77; Neuropeptide G-protein coupled receptor
Protein Family
Neuropeptide FF receptor
UniProt Gene Name
NPFFR2
UniProt Synonym Gene Names
GPR74; NPFF2; NPGPR
UniProt Entry Name
NPFF2_HUMAN
NCBI Protein Information
neuropeptide FF receptor 2; neuropeptide FF 2; OTTHUMP00000160367; OTTHUMP00000160368; OTTHUMP00000160369; G protein-coupled receptor 74; G-protein coupled receptor 74; G-protein coupled receptor HLWAR77; neuropeptide G-protein coupled receptor

NCBI Summary for NPFFR2

This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
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UniProt Comments for NPFFR2

NPFFR2: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: integral to plasma membrane; plasma membrane; actin cytoskeleton

Molecular Function: opioid receptor binding; G-protein coupled receptor activity; neuropeptide receptor activity; peptide binding

Biological Process: regulation of adenylate cyclase activity; G-protein coupled receptor protein signaling pathway; synaptic transmission; neuropeptide signaling pathway; regulation of MAPKKK cascade; detection of abiotic stimulus; cellular response to hormone stimulus
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Research Articles on NPFFR2

1. Besides regulation of reproduction, kisspeptins have a potential to mediate physiological effects on autonomic regulation and nociception in humans via the NPFF2R pathways.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NPFFR2 antibody

 Reference Product  PubMed Publications
 NPFF antibody  >1 publications with NPFFR2 and NPFF

Pathways associated with anti-NPFFR2 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Orexin And Neuropeptides FF And QRFP Bind To Their Respective Receptors Pathway antibodies  Orexin And Neuropeptides FF And QRFP Bind To Their Respective Receptors Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-NPFFR2 antibody

 Disease Name  Pubmed Publications
 Hydrocephalus Antibodies  >1 publications with NPFFR2 and Hydrocephalus
 Central Nervous System Neoplasms Antibodies  >1 publications with NPFFR2 and Central Nervous System Neoplasms
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