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SH2D1B Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6139027

Plays a role in controlling signal transduction through at least four receptors, CD84, SLAMF1, LY9 and CD244, expressed on the surface of professional antigen-presenting cells. More details

$1155 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SH2D1B, Monoclonal Antibody
Full Product Name
SH2D1B (SH2 Domain-containing Protein 1B, EWS/FLI1-activated Transcript 2, EAT-2, EAT2) (APC)
Product Gene Name
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
2B4
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human SH2D1B.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
15,297 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (162365056..162381928, complement). Location: 1q23.3
OMIM
608510
3D Structure
ModBase 3D Structure for O14796
Immunogen
Partial recombinant protein corresponding to aa54-132 from human SH2D1B with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
RIFREKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETFVNSNSDYVDVLP
Conjugate
APC
Applications Tested/Suitable for anti-SH2D1B antibody
FLISA, Immunoprecipitation (IP)
Application Notes for anti-SH2D1B antibody
Applications are based on unconjugated antibody.

Testing Data of anti-SH2D1B antibody

Detection limit is 0.3ng/ml using 133286 as a capture antibody.
Mouse Anti-SH2D1B Monoclonal Antibody – Cat# MBS6139027

Immunoprecipitation (IP) of anti-SH2D1B antibody

Immunoprecipitation of SH2D1B transfected lysate using 133286 and Protein A Magnetic Bead and immunoblotted with SH2D1B rabbit polyclonal antibody.
Mouse Anti-SH2D1B Monoclonal Antibody, Immunoprecipitation (IP) – Cat# MBS6139027

Other Notes

Small volumes of anti-SH2D1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SH2D1B purchase

MBS6139027 is an antibody targeting SH2D1B. Also known as SH2D1B (SH2 Domain-containing Protein 1B, EWS/FLI1-activated Transcript 2, EAT-2, EAT2) (APC). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SH2D1B. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
SH2 domain-containing protein 1B
NCBI Official Synonym Full Names
SH2 domain containing 1B
NCBI Official Symbol
SH2D1B
NCBI Official Synonym Symbols
EAT2
UniProt Protein Name
SH2 domain-containing protein 1B
UniProt Synonym Protein Names
EWS/FLI1-activated transcript 2
UniProt Gene Name
SH2D1B
UniProt Synonym Gene Names
EAT2; EAT-2
UniProt Entry Name
SH21B_HUMAN
NCBI Protein Information
SH2 domain-containing protein 1B; EAT-2; EWS/FLI1-activated transcript 2; SH2 domain-containing molecule EAT2

NCBI Summary for SH2D1B

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008]

UniProt Comments for SH2D1B

SH2D1B: Plays a role in controlling signal transduction through at least four receptors, CD84, SLAMF1, LY9 and CD244, expressed on the surface of professional antigen-presenting cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: intracellular

Molecular Function: protein binding, bridging; protein binding

Biological Process: leukocyte activation during immune response; positive regulation of innate immune response; positive regulation of natural killer cell mediated immunity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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