Rabbit Anti-CCL7 Polyclonal Antibody – Cat# MBS614047

CCL7 Antibody – Rabbit Polyclonal

Name: CCL7 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS614047
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS614047

Human macrophage/monocyte chemotactic protein-3 (MCP-3) is a 8.5kD protein containing 76 amino acids residues. It plays an important role in the inflammatory response of blood monocytes, tissue macrophages, and eosinophils. The gene encoding this protein… More details

$450 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MCP3 (CCL7), Polyclonal Antibody

Full Product Name

MCP3 (Macrophage/Monocyte Chemotactic Protein 3)

Product Gene Name

anti-CCL7 antibody

Product Synonym Names

Anti -MCP3 (Macrophage/Monocyte Chemotactic Protein 3)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.4, 40% glycerol.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography employing immobilized hMCP-3 matrix.

Specificity

Recognizes MCP-3

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

11,200 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (32597240..32599256). Location: 17q11.2-q12

OMIM

158106

3D Structure

ModBase 3D Structure for P80098

Immunogen

Highly purified (> 98%) recombinant hMCP-3 (human Macrophage/ Monocyte chemotactic protein-3).

Country of Origin

USA

Product Categories/Family for anti-CCL7 antibody

Antibodies; Abs to Growth Factors; Cytokines

Applications Tested/Suitable for anti-CCL7 antibody

ELISA (EL/EIA), Western Blot (WB), Neutralization

Application Notes for anti-CCL7 antibody

Sutiable for use in Neutralization, ELISA and Western Blot.
Dilution: Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity (100ng/ml), use a concentration of 3-4ug/ml.
ELISA: Detection by direct ELISA (using 100ul/well antibody solution), requires a concentration of at least 0.5ug/ml. This antigen-affinity purified antibody, in conjunction with compatible secondary reagents, allows detection of 0.2-0.4ng/well.
Western Blot: Use at a concentration of 0.1-0.2ug/ml. Used in conjunction with compatible secondary reagents the detection limit is 1.5-3.0ng/lane, under either reducing or non-reducing conditions.
Optimal dilutions to be determined by the researcher.

Other Notes

Small volumes of anti-CCL7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL7 purchase

MBS614047 is an antibody targeting CCL7. Also known as MCP3 (Macrophage/Monocyte Chemotactic Protein 3). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL7. It may not necessarily be applicable to this product.

NCBI GI #

2905626

NCBI GeneID

6354

UniProt Primary Accession #

P80098

UniProt Secondary Accession #

Q569J6

UniProt Related Accession #

P80098; Q7Z7Q8

NCBI Official Full Name

monocyte chemoattractant protein 3

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 7

NCBI Official Symbol

CCL7

NCBI Official Synonym Symbols

FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7; MGC138463; MGC138465

UniProt Protein Name

C-C motif chemokine 7

UniProt Synonym Protein Names

Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; NC28; Small-inducible cytokine A7

Protein Family

C-C motif chemokine

UniProt Gene Name

CCL7

UniProt Synonym Gene Names

MCP3; SCYA6; SCYA7

UniProt Entry Name

CCL7_HUMAN

NCBI Protein Information

C-C motif chemokine 7; OTTHUMP00000163801; small-inducible cytokine A7; monocyte chemotactic protein 3; monocyte chemoattractant protein 3; small inducible cytokine A7 (monocyte chemotactic protein 3)

NCBI Summary for CCL7

This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq]

UniProt Comments for CCL7

CCL7: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; CCR1 chemokine receptor binding; CCR2 chemokine receptor binding; chemokine activity

Biological Process: cellular calcium ion homeostasis; monocyte chemotaxis; regulation of cell shape; cell-cell signaling; eosinophil chemotaxis; response to gamma radiation; cytoskeleton organization and biogenesis; immune response; inflammatory response; signal transduction; chemotaxis; positive regulation of cell migration

Research Articles on CCL7

1. The expression of MCP-3 in laryngeal squamous cell carcinoma is much higher than in normal tissue.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCL7 antibody

Reference Product	PubMed Publications
CCR2 antibody	>68 publications with CCL7 and CCR2
CCR3 antibody	>40 publications with CCL7 and CCR3
CCR1 antibody	>34 publications with CCL7 and CCR1
CCR5 antibody	>31 publications with CCL7 and CCR5
MMP2 antibody	>3 publications with CCL7 and MMP2
CCR10 antibody	>3 publications with CCL7 and CCR10

Pathways associated with anti-CCL7 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with anti-CCL7 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>130 publications with CCL7 and Inflammation
Immune System Diseases Antibodies	>81 publications with CCL7 and Immune System Diseases
Lung Diseases Antibodies	>47 publications with CCL7 and Lung Diseases
Asthma Antibodies	>36 publications with CCL7 and Asthma
Neoplasms Antibodies	>33 publications with CCL7 and Neoplasms
Nervous System Diseases Antibodies	>25 publications with CCL7 and Nervous System Diseases
Skin Diseases Antibodies	>18 publications with CCL7 and Skin Diseases
Vascular Diseases Antibodies	>14 publications with CCL7 and Vascular Diseases
Fibrosis Antibodies	>14 publications with CCL7 and Fibrosis
Intestinal Diseases Antibodies	>13 publications with CCL7 and Intestinal Diseases

Organs/Tissues associated with anti-CCL7 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>212 publications with CCL7 and Blood
Lung Antibodies	>56 publications with CCL7 and Lung
Skin Antibodies	>24 publications with CCL7 and Skin
Intestine Antibodies	>9 publications with CCL7 and Intestine
Uterus Antibodies	>6 publications with CCL7 and Uterus
Placenta Antibodies	>3 publications with CCL7 and Placenta