Rabbit Anti-FRS2 Polyclonal Antibody – Cat# MBS614077

Western blot analysis of extracts from COS cells cotransfected with human FRS2-alpha and rat TrkA, and stimulated with or without NGF, using MBS614077. (Cell lysates provided by Dr. Susan Meakin, Robarts Research Institute, London, Ontario.)

Alpha (FRS2) Antibody – Rabbit Polyclonal

Name: FRS2 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS614077
Price: 830 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS614077

Fibroblast growth factor receptor substrate 2 (FRS2, also called Suc-associated neurotrophic factor-induced tyrosine- phosphorylated target or SNT) participates in the transmission of extracellular signals from the fibroblast growth factor receptor (FGFR).… More details

$830 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FRS2 alpha, Polyclonal Antibody

Full Product Name

FRS2 alpha, Phosphorylated (Tyr436) (Fibroblast Growth Factor Receptor Substrate 2, RS2, Suc-associated Neurotrophic Factor-induced Tyrosine-phosphorylated Target, SNT)

Product Gene Name

anti-FRS2 antibody

Product Synonym Names

Anti -FRS2 alpha, Phosphorylated (Tyr436) (Fibroblast Growth Factor Receptor Substrate 2, RS2, Suc-associated Neurotrophic Factor-induced Tyrosine-phosphorylated Target, SNT)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Purity/Purification

Affinity Purified
Purified by Protein A and Peptide affinity chromatography.

Specificity

Recognizes endogenous levels of human FRS2 alpha at ~80-85kD only when phosphorylated at Tyr436. Does not crossreact with unrelated tyrosine-phosphorylated proteins. Species Crossreactivity

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

57,029 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (69864129..69973573). Location: 12q15

OMIM

607743

3D Structure

ModBase 3D Structure for Q8WU20

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding Tyr436 of human FRS2 alpha.

Product Categories/Family for anti-FRS2 antibody

Antibodies; Abs to Transcription Factors

Applications Tested/Suitable for anti-FRS2 antibody

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)

Application Notes for anti-FRS2 antibody

Suitable for use in Western Blot, Immunoprecipitation and ELISA.
Dilution: Western Blot: 1:1000; Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4 degree C with gentle shaking, overnight.
Immunoprecipitation: 1:50

Other Notes

Small volumes of anti-FRS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FRS2 purchase

MBS614077 is an antibody targeting FRS2. Also known as FRS2 alpha, Phosphorylated (Tyr436) (Fibroblast Growth Factor Receptor Substrate 2, RS2, Suc-associated Neurotrophic Factor-induced Tyrosine-phosphorylated Target, SNT). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FRS2. It may not necessarily be applicable to this product.

NCBI GI #

110347408

NCBI GeneID

10818

NCBI Accession #

NP_006645.3

UniProt Primary Accession #

Q8WU20

UniProt Secondary Accession #

O43558; Q7LDQ6; B0LPF2; B2R684

UniProt Related Accession #

Q8WU20

GenBank Nucleotide #

NM_006654.4

NCBI Official Full Name

fibroblast growth factor receptor substrate 2

NCBI Official Synonym Full Names

fibroblast growth factor receptor substrate 2

NCBI Official Symbol

FRS2

NCBI Official Synonym Symbols

SNT; SNT1; FRS2A; SNT-1; FRS2alpha

UniProt Protein Name

Fibroblast growth factor receptor substrate 2

UniProt Synonym Protein Names

FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1

Protein Family

Fibroblast growth factor receptor substrate

UniProt Gene Name

FRS2

UniProt Synonym Gene Names

FGFR substrate 2; SNT-1

UniProt Entry Name

FRS2_HUMAN

NCBI Protein Information

fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR signalling adaptor; FGFR-signaling adaptor SNT; suc1-associated neurotrophic factor target 1

UniProt Comments for FRS2

FRS2: an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: membrane; integral to plasma membrane; plasma membrane; intercellular junction; endosome

Molecular Function: protein binding; phosphatase activator activity; neurotrophin TRKA receptor binding; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; activation of MAPKK activity; activation of MAPK activity; gastrulation with mouth forming second; regulation of epithelial cell proliferation; regulation of apoptosis; G-protein coupled receptor protein signaling pathway; determination of anterior/posterior axis, embryo; induction of an organ; forebrain development; neuroblast proliferation; insulin receptor signaling pathway; innate immune response; optic placode formation involved in camera-type eye; transmembrane receptor protein tyrosine phosphatase signaling pathway

Research Articles on FRS2

1. Patient with pigmentation disorders and vitiligo show decreased expression of mRNA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FRS2 antibody

Reference Product	PubMed Publications
FGFR1 antibody	>42 publications with FRS2 and FGFR1
GRB2 antibody	>37 publications with FRS2 and GRB2
SRC antibody	>31 publications with FRS2 and SRC
FGFR2 antibody	>24 publications with FRS2 and FGFR2
MAPK1 antibody	>13 publications with FRS2 and MAPK1
PTPN11 antibody	>13 publications with FRS2 and PTPN11
RET antibody	>10 publications with FRS2 and RET
CBL antibody	>6 publications with FRS2 and CBL
SOS1 antibody	>4 publications with FRS2 and SOS1
CRK antibody	>4 publications with FRS2 and CRK

Pathways associated with anti-FRS2 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies	Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram
FGF Signaling Pathway antibodies	FGF Signaling Pathway Diagram

Diseases associated with anti-FRS2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>45 publications with FRS2 and Neoplasms
Death Antibodies	>9 publications with FRS2 and Death
Bone Diseases Antibodies	>7 publications with FRS2 and Bone Diseases
Breast Neoplasms Antibodies	>5 publications with FRS2 and Breast Neoplasms
Genital Diseases, Male Antibodies	>5 publications with FRS2 and Genital Diseases, Male
Immune System Diseases Antibodies	>3 publications with FRS2 and Immune System Diseases
Cardiovascular Diseases Antibodies	>3 publications with FRS2 and Cardiovascular Diseases
Liver Diseases Antibodies	>2 publications with FRS2 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>2 publications with FRS2 and Carcinoma, Hepatocellular
Atherosclerosis Antibodies	>2 publications with FRS2 and Atherosclerosis

Organs/Tissues associated with anti-FRS2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>19 publications with FRS2 and Brain
Vascular Antibodies	>10 publications with FRS2 and Vascular
Muscle Antibodies	>8 publications with FRS2 and Muscle
Lung Antibodies	>7 publications with FRS2 and Lung
Embryonic Tissue Antibodies	>6 publications with FRS2 and Embryonic Tissue
Liver Antibodies	>5 publications with FRS2 and Liver
Prostate Antibodies	>5 publications with FRS2 and Prostate
Kidney Antibodies	>4 publications with FRS2 and Kidney
Blood Antibodies	>4 publications with FRS2 and Blood
Stomach Antibodies	>3 publications with FRS2 and Stomach