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Glucagon-Like Peptide 2 Receptor (GLP2R) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS614220

Glucagon is a member of a multigene family comprising of Secretin, Vasoactive Intestinal Peptide (VIP), Gastric Inhibitory Peptide (GIP) and others like Glicentin and Oxyntomodulin (OXM), which differs from glucagon by C-terminal octapeptide. The glucagon… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Glucagon-like Peptide 2 Receptor (GLP2R), Polyclonal Antibody
Full Product Name
Glucagon-like Peptide 2 Receptor (GLP2R)
Product Gene Name
anti-GLP2R antibody
Product Synonym Names
Anti -Glucagon-like Peptide 2 Receptor (GLP2R)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human GLP2R. Species sequence homology: mouse-85%, rat-75%.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
63,001 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (9729381..9793022). Location: 17p13.3
OMIM
603659
3D Structure
ModBase 3D Structure for O95838
Immunogen
Synthetic peptide, 20aa corresponding to mid-region, cytoplasmic of human GLP2R.

Product Categories/Family for anti-GLP2R antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-GLP2R antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-GLP2R antibody
Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1-10ug/ml using Chemiluminescence technique.
ELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml (See G2040-39H).

Other Notes

Small volumes of anti-GLP2R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLP2R purchase

MBS614220 is an antibody targeting GLP2R. Also known as Glucagon-like Peptide 2 Receptor (GLP2R). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GLP2R. It may not necessarily be applicable to this product.

NCBI GI #
4758438
NCBI GeneID
9340
NCBI Accession #
NP_004237.1
UniProt Primary Accession #
O95838
UniProt Secondary Accession #
Q4VAT3
UniProt Related Accession #
O95838; Q4VAT1; Q4VAT2; Q4VAT4; Q86XI5; Q86YG9; Q8WUR8
GenBank Nucleotide #
NM_004246.1
NCBI Official Full Name
glucagon-like peptide 2 receptor
NCBI Official Synonym Full Names
glucagon-like peptide 2 receptor
NCBI Official Symbol
GLP2R
NCBI Official Synonym Symbols
GLP2R
UniProt Protein Name
Glucagon-like peptide 2 receptor
Protein Family
Glucagon-like peptide 2 receptor
UniProt Gene Name
GLP2R
UniProt Entry Name
GLP2R_HUMAN
NCBI Protein Information
glucagon-like peptide 2 receptor; GLP-2R; GLP-2-R; GLP-2 receptor; OTTHUMP00000160769

NCBI Summary for GLP2R

The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R). [provided by RefSeq]
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UniProt Comments for GLP2R

GLP2R: This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; glucagon receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; positive regulation of cell proliferation
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Research Articles on GLP2R

1. docking studies were performed between the N-terminal extracellular domain of GLP-2 receptor and the GLP-2 hormone

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GLP2R antibody

 Reference Product  PubMed Publications
 GCG antibody  >2 publications with GLP2R and GCG

Pathways associated with anti-GLP2R antibody

 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Glucagon-type Ligand Receptors Pathway antibodies  Glucagon-type Ligand Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Organs/Tissues associated with anti-GLP2R antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >4 publications with GLP2R and Intestine
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