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Interleukin 22r (IL22RA1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS614297

A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified (1-3). The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Interleukin 22R (IL22RA1), Polyclonal Antibody
Full Product Name
Interleukin 22R, NT (IL-22R NT, CRF2-9, IL-TIF R1, IL-10 Related T Cell-derived Inducible Factor)
Product Gene Name
anti-IL22RA1 antibody
Product Synonym Names
Anti -Interleukin 22R, NT (IL-22R NT, CRF2-9, IL-TIF R1, IL-10 Related T Cell-derived Inducible Factor)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
100ug in 200ul of PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Immunoaffinity purified IgG
Specificity
Human Interleukin-22R. An approximately 62kD band can be detected.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C or colder. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
63,077 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (24446261..24469783, complement). Location: 1p36.11
OMIM
605457
3D Structure
ModBase 3D Structure for Q8N6P7
Immunogen
Synthetic peptide (QSSNFENILTWDSGPE) corresponding to amino acids 31 to 46 of human IL-22R precursor (1).

Product Categories/Family for anti-IL22RA1 antibody

Antibodies; Abs to Interleukin
Applications Tested/Suitable for anti-IL22RA1 antibody
Western Blot (WB), Neutralization
Application Notes for anti-IL22RA1 antibody
Suitable for use in Western Blotting.
Dilution: 0.5-1ug/ml
Human HepG2 cell lysate can be used as positive control.

Western Blot (WB) of anti-IL22RA1 antibody

Western blot analysis of IL-22R expression in human HepG2 cell lysate with anti-IL-22R (CT) at 1 ug /ml.
Rabbit Anti-IL22RA1 Polyclonal Antibody – Cat# MBS614297

Immunohistochemistry (IHC) of anti-IL22RA1 antibody

Immunohistochemical analysis of MBS614297.
Rabbit Anti-IL22RA1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS614297

Other Notes

Small volumes of anti-IL22RA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL22RA1 purchase

MBS614297 is an antibody targeting IL22RA1. Also known as Interleukin 22R, NT (IL-22R NT, CRF2-9, IL-TIF R1, IL-10 Related T Cell-derived Inducible Factor). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL22RA1. It may not necessarily be applicable to this product.

NCBI GI #
31317239
NCBI GeneID
58985
NCBI Accession #
NP_067081.2
UniProt Primary Accession #
Q8N6P7
UniProt Secondary Accession #
Q9HB22; A8K839; B2R9Y9
UniProt Related Accession #
Q8N6P7
GenBank Nucleotide #
NM_021258.3
NCBI Official Full Name
interleukin-22 receptor subunit alpha-1
NCBI Official Synonym Full Names
interleukin 22 receptor, alpha 1
NCBI Official Symbol
IL22RA1
NCBI Official Synonym Symbols
IL22R; CRF2-9; IL22R1
UniProt Protein Name
Interleukin-22 receptor subunit alpha-1
UniProt Synonym Protein Names
Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; CRF2-9; ZcytoR11
Protein Family
Interleukin-22 receptor
UniProt Gene Name
IL22RA1
UniProt Synonym Gene Names
IL22R; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; CRF2-9
UniProt Entry Name
I22R1_HUMAN
NCBI Protein Information
interleukin-22 receptor subunit alpha-1; IL-22RA1; zcytoR11; IL-22R-alpha-1; IL-22 receptor subunit alpha-1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9

NCBI Summary for IL22RA1

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL22RA1

IL22RA1: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: integral to membrane; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interferon receptor activity; interleukin-20 binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to Gram-negative bacterium
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Research Articles on IL22RA1

1. Data show that IL-17RA, IL-17RC, IL-22R1, ERK1/2 MAPK and NF-kappaB pathways are involved in Th17 cytokine-induced proliferation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL22RA1 antibody

 Reference Product  PubMed Publications
 IL22 antibody  >3 publications with IL22RA1 and IL22
 IL20 antibody  >1 publications with IL22RA1 and IL20
 IL24 antibody  >1 publications with IL22RA1 and IL24
 IL10RB antibody  >1 publications with IL22RA1 and IL10RB

Pathways associated with anti-IL22RA1 antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-IL22RA1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with IL22RA1 and Breast Neoplasms
 Atherosclerosis Antibodies  >1 publications with IL22RA1 and Atherosclerosis
 Neoplasms Antibodies  >1 publications with IL22RA1 and Neoplasms
 Inflammation Antibodies  >1 publications with IL22RA1 and Inflammation

Organs/Tissues associated with anti-IL22RA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >1 publications with IL22RA1 and Thyroid
 Skin Antibodies  >1 publications with IL22RA1 and Skin
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