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Lifeguard (FAIM2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS614416

MBS614416 is an antibody targeting FAIM2. Also known as Lifeguard (LFG, Fas Apoptotic Inhibitory Molecule 2, FAIM2, NMP35). Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$835 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Lifeguard (FAIM2), Polyclonal Antibody
Full Product Name
Lifeguard (LFG, Fas Apoptotic Inhibitory Molecule 2, FAIM2, NMP35)
Product Gene Name
anti-FAIM2 antibody
Product Synonym Names
Anti -Lifeguard (LFG, Fas Apoptotic Inhibitory Molecule 2, FAIM2, NMP35)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes Human Lifeguard (KIAA0950) (FAIM2). Species Crossreactivity: Human, Mouse, Rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
35,110 Da
Chromosome Location
chromosome: 12; Location: 12q13
OMIM
604306
3D Structure
ModBase 3D Structure for Q9BWQ8
Immunogen
Synthetic peptide, KLH-conjugated. Epitope: 16 amino acid peptide from near the amino terminus of human LFG.

Product Categories/Family for anti-FAIM2 antibody

Antibodies; Abs to Apoptosis
Applications Tested/Suitable for anti-FAIM2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-FAIM2 antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry: 5ug/ml

Immunohistochemistry (IHC) of anti-FAIM2 antibody

FAIM2 (5ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human brain, cortex, followed by biotinylated goat rabbit IgG secondary, alkaline phosphatase-streptavidin and chromogen.
Rabbit Anti-FAIM2 Polyclonal Antibody – Cat# MBS614416

Other Notes

Small volumes of anti-FAIM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FAIM2. It may not necessarily be applicable to this product.

NCBI GI #
6273281
NCBI GeneID
23017
UniProt Primary Accession #
Q9BWQ8
UniProt Secondary Accession #
Q9UJY9; Q9Y2F7; A8K1W6
UniProt Related Accession #
Q9BWQ8
NCBI Official Full Name
lifeguard
NCBI Official Synonym Full Names
Fas apoptotic inhibitory molecule 2
NCBI Official Symbol
FAIM2
NCBI Official Synonym Symbols
LFG; LFG2; NGP35; NMP35; TMBIM2; KIAA0950; FAIM2
UniProt Protein Name
Fas apoptotic inhibitory molecule 2
UniProt Synonym Protein Names
Protein lifeguard; Transmembrane BAX inhibitor motif-containing protein 2
Protein Family
Protein lifeguard
UniProt Gene Name
FAIM2
UniProt Synonym Gene Names
KIAA0950; LFG; TMBIM2
UniProt Entry Name
FAIM2_HUMAN
NCBI Protein Information
fas apoptotic inhibitory molecule 2; lifeguard; protein lifeguard; neural membrane protein 35; transmembrane BAX inhibitor motif containing 2; transmembrane BAX inhibitor motif-containing protein 2

UniProt Comments for FAIM2

FAIM2: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. Belongs to the BI1 family. LFG subfamily.

Protein type: Apoptosis; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: postsynaptic membrane; integral to membrane; cell junction; lipid raft

Biological Process: cerebellar granular layer development; apoptosis; regulation of neuron apoptosis; cerebellar Purkinje cell differentiation; cerebellar Purkinje cell layer development; cerebellum development; negative regulation of neuron apoptosis; negative regulation of apoptosis
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Research Articles on FAIM2

1. LFG is strongly expressed in breast cancer epithelial cells. Moreover, the overexpression of LFG correlated with tumour grade and reduced Fas sensitivity.
2. Data show that SNPs in SEC16B and TMEM18 were significantly associated with obesity, and the SNPs in GNPDA2, BDNF, FAIM2 and MC4R were marginally associated with obesity in Japanese.
3. Observational study of gene-disease association. (HuGE Navigator)
4. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
5. The tmbim2 may participate in cell death regulation by interacting with proteins of Bcl-2 family, promoting tumor metastasis, which is deduced from the evolutionary conservation of the membrane protein family containing multiple membrane spanning segments
6. Human keratinocytes were transfected with either Flip, Faim, or Lifeguard (LFG). Our results suggest that heterotopic expression of antiapoptotic proteins can induce the resistance of keratinocytes to a major mechanism of rejection.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FAIM2 antibody

 Reference Product  PubMed Publications
 FAS antibody  >9 publications with FAIM2 and FAS

Pathways associated with anti-FAIM2 antibody

 Products by Pathway  Pathway Diagram
 FAS (CD95) Signaling Pathway antibodies  FAS (CD95) Signaling Pathway Diagram

Diseases associated with anti-FAIM2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with FAIM2 and Neoplasms
 Breast Neoplasms Antibodies  >2 publications with FAIM2 and Breast Neoplasms
 Glioma Antibodies  >1 publications with FAIM2 and Glioma
 Necrosis Antibodies  >1 publications with FAIM2 and Necrosis
 Brain Ischemia Antibodies  >1 publications with FAIM2 and Brain Ischemia
 Fibrosarcoma Antibodies  >1 publications with FAIM2 and Fibrosarcoma

Organs/Tissues associated with anti-FAIM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with FAIM2 and Brain
 Nerve Antibodies  >2 publications with FAIM2 and Nerve
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