SLC27A1 Antibody – Mouse Monoclonal

SLC27A1: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Belongs to the ATP-dependent AMP-binding enzyme family.

Protein type: EC 6.2.1.-; Ligase; Lipid-binding; Membrane protein, integral; Mitochondrial; Vesicle

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: endoplasmic reticulum; integral component of membrane; membrane; plasma membrane

Molecular Function: fatty acid transmembrane transporter activity; long-chain-fatty-acid-CoA ligase activity; nucleotide binding; protein homodimerization activity; very long-chain fatty acid-CoA ligase activity

Biological Process: adiponectin-activated signaling pathway; cardiolipin biosynthetic process; long-chain fatty acid metabolic process; long-chain fatty acid transport; medium-chain fatty acid transport; phosphatidic acid biosynthetic process; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process; phosphatidylglycerol biosynthetic process; phosphatidylinositol biosynthetic process; phosphatidylserine biosynthetic process; positive regulation of heat generation; regulation of lipid metabolic process; response to cold; response to insulin stimulus